Results 41 to 50 of about 1,660,275 (266)

A compact, versatile drug-induced splicing switch system with minimal background expression

Cell Reports: Methods
Summary: Gene-switch techniques hold promising applications in contemporary genetics research, particularly in disease treatment and genetic engineering.
Yue Chi, Xuan Lu, Shuangpeng Li, Jinling Wang, Jiahui Xi, Xiaoqing Zhou, Chengcheng Tang, Min Chen, Hui Yuan, Shuo Lin, Yingying Xiao, Liangxue Lai, Qingjian Zou   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum

Veterinary Sciences
Caffeic acid phenethyl ester (CAPE) is one of the main active components of the natural medicine propolis, which has antioxidant, anti-tumor, and immunomodulatory activities. This study aimed to analyze the effects and underlying mechanisms of CAPE added
Chu-Man Huang, Hui-Mei Huang, Ying-Hua Li, Xing-Wei Liang, Nam-Hyung Kim, Yong-Nan Xu   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction

Biomolecules
Parabens are widely used in various industries, which are including chemical, pharmaceutical, food, cosmetic, and plastic processing industries. Among these, methyl paraben (MP) serves as an antimicrobial preservative in processed foods, pharmaceuticals,
Huimei Huang, Chuman Huang, Yinghua Li, Xingwei Liang, Namhyung Kim, Yongnan Xu   +5 more
doaj   +1 more source

miR-146a-5p Plays an Oncogenic Role in NSCLC via Suppression of TRAF6

Frontiers in Cell and Developmental Biology, 2020
Non-small cell lung cancer (NSCLC) is the most deadly cancer in the world due to its often delayed diagnosis. Identification of biomarkers with high sensitivity, specificity, and accessibility for early detection, such as circulating microRNAs, is ...
Xiangdong Liu, Xiangdong Liu, Xiangdong Liu, Bo Liu, Bo Liu, Bo Liu, Ruihua Li, Fei Wang, Fei Wang, Fei Wang, Ning Wang, Ning Wang, Ning Wang, Maihe Zhang, Maihe Zhang, Maihe Zhang, Yang Bai, Yang Bai, Yang Bai, Jin Wu, Jin Wu, Jin Wu, Liping Liu, Liping Liu, Liping Liu, Dongyu Han, Dongyu Han, Dongyu Han, Zhiguang Li, Bin Feng, Guangbiao Zhou, Shujing Wang, Shujing Wang, Li Zeng, Li Zeng, Li Zeng, Jian Miao, Yiqun Yao, Bin Liang, Lin Huang, Lin Huang, Qi Wang, Yingjie Wu, Yingjie Wu, Yingjie Wu, Yingjie Wu, Yingjie Wu   +46 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease

Antioxidants, 2020
Coenzyme Q10 (Q10) is a mitochondrial cofactor and an antioxidant with the potential to combat oxidative stress in heart failure. This study aims to determine the pharmacokinetics of repeated oral dosing of Q10 in Cavalier King Charles Spaniels (CKCS ...
Liselotte B. Christiansen, Malene K. Morsing, Maria Josefine Reimann, Torben Martinussen, Zita Birlie, Anne Marie V. Schou-Pedersen, Jens Lykkesfeldt, Lisbeth H. Olsen   +7 more
doaj   +1 more source