Results 41 to 50 of about 9,617,821 (263)

Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

iScience, 2019
Summary: Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in ...
Liyuan Ran, Xiaoshuang Wang, Ai Mi, Yanshuang Liu, Jin Wu, Haoan Wang, Meihua Guo, Jie Sun, Bo Liu, Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Lin Huang, Xiaoli Chen, Derek LeRoith, Bin Liang, Xin Li, Yingjie Wu   +20 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment

Cancer Cell International
Lysosomes, as crucial organelles within cells, carry out diverse biological functions such as waste degradation, regulation of the cellular environment, and precise control of cell signaling.
Jianlei Bi, Yincong Sun, Meihua Guo, Xiaoxin Sun, Jie sun, Rujiao Jiang, Ning Wang, Gena Huang   +7 more
doaj   +1 more source

Leishmania Animal Models Used in Drug Discovery: A Systematic Review

, 2023
Many different animal models are in use for drug development for leishmaniasis, but a universal model does not exist. There is a plethora of models, and this review assesses their design, quality, and limitations, including the attention paid to animal ...
Henk D. F. H. Schallig, Jacob van der Ende   +1 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A compact, versatile drug-induced splicing switch system with minimal background expression

Cell Reports: Methods
Summary: Gene-switch techniques hold promising applications in contemporary genetics research, particularly in disease treatment and genetic engineering.
Yue Chi, Xuan Lu, Shuangpeng Li, Jinling Wang, Jiahui Xi, Xiaoqing Zhou, Chengcheng Tang, Min Chen, Hui Yuan, Shuo Lin, Yingying Xiao, Liangxue Lai, Qingjian Zou   +12 more
doaj   +1 more source

Transforming Intensive Animal Production: Challenges and Opportunities for Farm Animal Welfare in the European Union

, 2022
SIMPLE SUMMARY: The European Union (EU) has made commitments to review all established policies on farm animal welfare and by the end of 2023 propose new regulations that will improve farming conditions and phase out the use of cage-based systems. A case
Mariann Molnár, Molnár, Mariann
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mathematical modelling in animal nutrition: a centenary review [PDF]

, 2008
A centenary review presents an opportunity to ponder over the processes of concept development and give thought to future directions. The current review aims to ascertain the ontogeny of current concepts, underline the connection between ideas and people
Dijkstra, J., Dumas, A., France, J., J. DIJKSTRA, A. DUMAS, J. FRANCE   +5 more
core   +1 more source

Consumers’ Concerns and Perceptions of Farm Animal Welfare [PDF]

, 2020
P. 1-13In this paper, we explore the evolution of consumers’ perceptions and concerns about the effects that intensification of production systems could have on the welfare of farm animals.
José R. González-Montaña, Juan M. Lomillos, Lomillos Pérez, Juan Manuel, Alonso de la Varga, Marta Elena, González Montaña, José Ramiro, Marta E. Alonso   +5 more
core   +1 more source