Results 51 to 60 of about 9,968,795 (309)

Animal population social structure models [PDF]

, 2017
We develop a new class of mathematical ranking models for the purpose of quantifying the social structure in animal populations. Our approach is based on taking into account both the interaction between single individuals as well as their role within ...
Thomas P. Wihler, Wihler, Thomas
core   +2 more sources

Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment

Cancer Cell International
Lysosomes, as crucial organelles within cells, carry out diverse biological functions such as waste degradation, regulation of the cellular environment, and precise control of cell signaling.
Jianlei Bi, Yincong Sun, Meihua Guo, Xiaoxin Sun, Jie sun, Rujiao Jiang, Ning Wang, Gena Huang   +7 more
doaj   +1 more source

Diosmetin Delays In Vitro Aging of Porcine Oocytes by Improving Mitochondrial Function and Reducing Oxidative Stress

Animals
Oocyte quality is crucial for successful fertilization and subsequent embryonic development. Post-ovulatory aging leads to reduced oocyte quality and impaired embryogenesis, representing an unavoidable challenge in terms of certain assisted reproductive ...
Jia-Jun Ren, Xiu-Wen Yuan, Yu-Hao Zhang, Zi-Long Meng, Xing-Wei Liang, Nam-Hyung Kim, Yong-Nan Xu, Ying-Hua Li   +7 more
doaj   +1 more source

Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

iScience, 2019
Summary: Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in ...
Liyuan Ran, Xiaoshuang Wang, Ai Mi, Yanshuang Liu, Jin Wu, Haoan Wang, Meihua Guo, Jie Sun, Bo Liu, Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Lin Huang, Xiaoli Chen, Derek LeRoith, Bin Liang, Xin Li, Yingjie Wu   +20 more
doaj   +1 more source

Heterozygous lipoprotein lipase knockout mice exhibit impaired hematopoietic stem/progenitor cell compartment

Animal Models and Experimental Medicine, 2021
Background Hematopoietic stem cells (HSC) maintain the hematopoietic system homeostasis through self‐renewal and multilineage differentiation potential. HSC are regulated by the microenvironment, cytokine signaling, and transcription factors.
Guiying Shi, Xinyue Li, Keya Li, Yiying Huang, Xuepei Lei, Lin Bai, Chuan Qin   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Animal modeling in bone research—Should we follow the White Rabbit?

, 2019
Animal models are live subjects applied to translational research. They provide insights into human diseases and enhance biomedical knowledge. Livestock production has favored the pace of human social development over millennia.
Monteiro, Bianca Fiuza, Ísis dos Santos Dal‐Bó, Bregadioli, Thales, Aline Schafrum Macedo, Gabriel Antonio Covino Diamante, Macedo, Aline Schafrum, Cassio Ricardo Auada Ferrigno, Bianca Fiuza Monteiro, Dal-Bo, Isis dos Santos, Thales Bregadioli, Covino Diamante, Gabriel Antonio, Kitamura Kawamoto, Fernando Yoiti [UNESP], Caroline Cezaretti Feitosa, Paulo Vinicius Tertuliano Marinho, Feitosa, Caroline Cezaretti, Auada Ferrigno, Cassio Ricardo, Prado, Leonardo, Fernando Yoiti Kitamura Kawamoto, Leonardo Prado, Tertuliano Marinho, Paulo Vinicius   +19 more
core   +1 more source

A compact, versatile drug-induced splicing switch system with minimal background expression

Cell Reports: Methods
Summary: Gene-switch techniques hold promising applications in contemporary genetics research, particularly in disease treatment and genetic engineering.
Yue Chi, Xuan Lu, Shuangpeng Li, Jinling Wang, Jiahui Xi, Xiaoqing Zhou, Chengcheng Tang, Min Chen, Hui Yuan, Shuo Lin, Yingying Xiao, Liangxue Lai, Qingjian Zou   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source