Results 121 to 130 of about 24,835,738 (277)
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Data-driven modelling of biological multi-scale processes
, 2015 Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales.
Hasenauer, Jan +3 more
core +1 more source
Model Checking Biological Oscillators
Electronic Notes in Theoretical Computer Science, 2009 AbstractWe define a subclass of timed automata, called oscillator timed automata, suitable to model biological oscillators. The semantics of their interactions, parametric w.r.t. a model of synchronization, is introduced. We apply it to the Kuramoto model.
BARTOCCI, Ezio +3 more
openaire +2 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Stability of a neural network model with small-world connections
, 2004 Small-world networks are highly clustered networks with small distances among the nodes. There are many biological neural networks that present this kind of connections.
C. Aguirre +15 more
core +1 more source
Membrane Electroporation and Electropermeabilization: Mechanisms and Models.
Annual Review of Biophysics, 2019 Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise impermeant molecules.
T. Kotnik +3 more
semanticscholar +1 more source
Molecules, 2016 The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery.
Guan-Nan Liu +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods
International Journal of Molecular Sciences, 2016 Molecular recognition, which is the process of biological macromolecules interacting with each other or various small molecules with a high specificity and affinity to form a specific complex, constitutes the basis of all processes in living organisms ...
Xing Du +7 more
semanticscholar +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source