Results 121 to 130 of about 30,009,286 (350)

Slightly generalized Generalized Contagion: Unifying simple models of biological and social spreading

, 2017
We motivate and explore the basic features of generalized contagion, a model mechanism that unifies fundamental models of biological and social contagion.
C Castillo-Chavez, DJ Daley, DJ Daley, DJ Watts, DJ Watts, DJ Watts, F Bass, JD Murray, JP Gleeson, L Weng, M Granovetter, MS Granovetter, MS Granovetter, PS Dodds, PS Dodds, PS Dodds, SH Strogatz, TC Schelling, TC Schelling, W Goffman, WO Kermack, WO Kermack, WO Kermack   +22 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

LVI and DI-SPME Combined with GC/MS and GC/MS for Volatile Chemical Profile Investigation and Cytotoxic Power Evaluation of Essential Oil and Hydrolate from Cannabis sativa L. cv. Carmagnola

Molecules
Cannabis sativa L. is a plant that has been cultivated since ancient times thanks to its various uses. Even its extraction products, such as essential oil and hydrolate, having a varied chemical composition and rich in bioactive components, find wide use
Vittorio Vinciguerra, Marta Di Martile, Monica Mollica Graziano, Donatella Del Bufalo, Stefania Garzoli   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas

npj Regenerative Medicine
Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness.
Egidijus Simoliunas, Inés Ruedas-Torres, Yolanda Jiménez-Gómez, Elle Edin, Mozhgan Aghajanzadeh-Kiyaseh, Mostafa Zamani-Roudbaraki, Rimvydas Asoklis, Milda Alksne, Neethi C. Thathapudi, Bijay K. Poudel, Ieva Rinkunaite, Kasparas Asoklis, Monika Iesmantaite, Laura Ortega-Llamas, Almantas Makselis, Marcelo Munoz, Daiva Baltriukiene, Virginija Bukelskiene, Jaime Gómez-Laguna, Miguel González-Andrades, May Griffith   +20 more
doaj   +1 more source

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria

Nature Communications, 2017
Carrageenans, major cell wall polysaccharides of red macroalgae, are metabolised by marine heterotrophic bacteria through unclear mechanisms. Here, the authors identify an unusual polysaccharide-utilization locus encoding carrageenan catabolism in a ...
Elizabeth Ficko-Blean, Aurélie Préchoux, François Thomas, Tatiana Rochat, Robert Larocque, Yongtao Zhu, Mark Stam, Sabine Génicot, Murielle Jam, Alexandra Calteau, Benjamin Viart, David Ropartz, David Pérez-Pascual, Gaëlle Correc, Maria Matard-Mann, Keith A. Stubbs, Hélène Rogniaux, Alexandra Jeudy, Tristan Barbeyron, Claudine Médigue, Mirjam Czjzek, David Vallenet, Mark J. McBride, Eric Duchaud, Gurvan Michel   +24 more
doaj   +1 more source

Dynamics of Pathological and Virological Findings During Experimental Calpox Virus Infection of Common Marmosets (Callithrix jacchus)

Viruses, 2017
Experimental intranasal infection of marmosets (Callithrix jacchus) with calpox virus results in fatal disease. Route and dose used for viral inoculation of the test animals mimics the natural transmission of smallpox, thus representing a suitable model ...
Anne Schmitt, Li Lin Gan, Ahmed Abd El Wahed, Tingchuan Shi, Heinz Ellerbrok, Franz-Josef Kaup, Christiane Stahl-Hennig, Kerstin Mätz-Rensing   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Quasilinear and singular elliptic systems

, 2013
In this paper, we investigate a general quasilinear elliptic and singular system. By monotonicity methods, we give some existence and uniqueness results.
Giacomoni, Jacques, Hernández, Jesús, Sauvy, Paul   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source