Results 141 to 150 of about 10,674,828 (317)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Extracellular Matrix Sulfation in the Tumor Microenvironment Stimulates Cancer Stemness and Invasiveness

Advanced Science
Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kinase (RTK ...
Alican Kuşoğlu, Deniz Örnek, Aslı Dansık, Ceren Uzun, Sena Nur Özkan, Sevgi Sarıca, Kardelen Yangın, Şevval Özdinç, Duygu Turan Sorhun, Nuriye Solcan, Efe Can Doğanalp, Øystein Arlov, Katherine Cunningham, Ismail C. Karaoğlu, Seda Kizilel, Ihsan Solaroğlu, Pınar Bulutay, Pınar Fırat, Suat Erus, Serhan Tanju, Şükrü Dilege, Gordana Vunjak‐Novakovic, Nurcan Tuncbag, Ece Öztürk   +23 more
doaj   +1 more source

Annual Report - Marine Biological Laboratory, 1965

, 1966
Annual report of the Marine Biological Laboratory in Woods Hole. 1965.
Marine Biological Laboratory (Woods Hole MA)
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Biological Models of Reinforcement Learning

Künstliche Intell., 2009
This review focuses on biological issues of reinforcement learning. Since the influential discovery of W. Schultz of an analogy between the reward prediction error signal of the temporal difference algorithm and the firing pattern of some dopaminergic neurons in the midbrain during classical conditioning, biological models have emerged that use ...
Vitay, Julien, Fix, Jérémy, Beuth, Frederik, Schroll, Henning, Hamker, Fred   +4 more
openaire   +2 more sources

Annual Report - Marine Biological Laboratory, 1944

, 1945
Annual report of the Marine Biological Laboratory in Woods Hole. 1944.
Marine Biological Laboratory (Woods Hole MA)
core  

Annual Report - Marine Biological Laboratory, 2013 [PDF]

, 2011
Annual report of the Marine Biological Laboratory in Woods Hole. 2013. Includes lists of students, faculty, and researchers.Published in two parts. Printed document includes message from the President & Director, highlights, MBL at-a-glance, finanicals,
Marine Biological Laboratory (Woods Hole MA)
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1910

, 1911
Annual report of the Marine Biological Laboratory in Woods Hole. 1910.
Marine Biological Laboratory (Woods Hole MA)
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source