Results 101 to 110 of about 1,977,773 (318)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

3D Microporous Scaffolds Manufactured via Combination of Fused Filament Fabrication and Direct Laser Writing Ablation

Micromachines, 2014
A 3D printing fused filament fabrication (FFF) approach has been implemented for the creation of microstructures having an internal 3D microstructure geometry. These objects were produced without any sacrificial structures or additional support materials,
Mangirdas Malinauskas, Sima Rekštytė, Laurynas Lukoševičius, Simas Butkus, Evaldas Balčiūnas, Milda Pečiukaitytė, Daiva Baltriukienė, Virginija Bukelskienė, Arūnas Butkevičius, Povilas Kucevičius, Vygandas Rutkūnas, Saulius Juodkazis   +11 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes

Frontiers in Pharmacology
BackgroundType 1 diabetes (T1D) is an autoimmune disease that leads to the progressive destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycemia. Current treatments focus on insulin replacement, but novel therapeutic approaches
Šarūnas Tumas, Jonas Mingaila, Vytautas Baranauskas, Vytautas Baranauskas, Emilija Baltrukonytė, Laurynas Orla, Jan Aleksander Krasko, Roberta Pocevičiūtė, Dina Berlina, Alexei Belenky, Maria Vilenchik, Agnė Vaitkevičienė, Olga Potapova, Aurelijus Burokas   +13 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

On Crowd-verification of Biological Networks [PDF]

, 2013
Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can become unwieldy to manage as their size and complexity increase.
Kahn Rhrissorrakrai, Raquel Norel, Anita Iskandar, Stephanie Boue, Walter K. Schlage, Jean Binder, Dexter Pratt, Sam Ansari, Robin Kleiman, Bruce O'Neel, Marja Talikka, Manuel C. Peitsch, William Hayes, Carine Poussin, Julia Hoeng, The sbv IMPROVER project team (in alphabetical order): Sam Ansari, Gustavo Stolovitzky, Anselmo Di Fabio   +17 more
core   +1 more source

Investigating tryptophan-producing probiotic lactic acid bacteria from Lithuanian fermented foods: functional characterization, safety evaluation, and genomic analysis

Journal of Functional Foods
This study aimed to isolate and characterize lactic acid bacteria (LAB) from traditional Lithuanian fermented foods and evaluate their probiotic potential, safety, and ability to produce tryptophan.
Ashwinipriyadarshini Megur, Kamilė Ambrutaitytė, Mikas Sadauskas, Jonita Stankevičiūtė, Rolandas Meškys, Eglė Lastauskienė, Aurelijus Burokas   +6 more
doaj   +1 more source

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

Molecules, 2016
The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery.
Guan-Nan Liu, Rong-Hua Luo, Yu Zhou, Xing-Jie Zhang, Jian Li, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source