Results 141 to 150 of about 24,835,738 (277)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Slightly generalized Generalized Contagion: Unifying simple models of biological and social spreading

, 2017
We motivate and explore the basic features of generalized contagion, a model mechanism that unifies fundamental models of biological and social contagion.
C Castillo-Chavez, DJ Daley, DJ Daley, DJ Watts, DJ Watts, DJ Watts, F Bass, JD Murray, JP Gleeson, L Weng, M Granovetter, MS Granovetter, MS Granovetter, PS Dodds, PS Dodds, PS Dodds, SH Strogatz, TC Schelling, TC Schelling, W Goffman, WO Kermack, WO Kermack, WO Kermack   +22 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Quasilinear and singular elliptic systems

, 2013
In this paper, we investigate a general quasilinear elliptic and singular system. By monotonicity methods, we give some existence and uniqueness results.
Giacomoni, Jacques, Hernández, Jesús, Sauvy, Paul   +2 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Integrated ecological modelling for decision support in river management: a lowland river case study (Cauca river in Colombia) [PDF]

, 2010
Several practical concepts and software systems have been recently developed in the issue of environmental decision support. However, the application of ecological modelling approaches that integrate hydrodynamic, physical-chemical, and biological ...
Galvis, Alberto, Goethals, Peter, Holguin Gonzalez, Javier   +2 more
core   +1 more source

Corrigendum to: Draft genome sequence dataset of Latilactobacillus curvatus PN39MY isolated from fermented vegetables Data in Brief, 49 (2023) 109436

Data in Brief, 2023
Eric Banan-Mwine Daliri, Toma Balnionytė, Eglė Lastauskienė, Aurelijus Burokas   +3 more
doaj   +1 more source

Biocompatibility of Hydraulic Calcium Silicate-Based Cement MTA Flow^TM on Human Dental Pulp Stem Cells In Vitro

Journal of Functional Biomaterials
Aim: hydraulic calcium silicate-based cements (HCSCs) are widely used in endodontics for vital pulp therapy and other clinical procedures due to their favorable physicochemical and biological properties.
Paulius Tušas, Josette Camilleri, Milda Alksnė, Egidijus Šimoliūnas, Saulius Drukteinis, Eglė Marija Urbonė, Virginija Bukelskienė, Vygandas Rutkūnas, Vytautė Pečiulienė   +8 more
doaj   +1 more source