Results 41 to 50 of about 2,719,550 (270)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Tools and Procedures of the Science Officer in the Management of Hazardous-Material Incidents

CHIMIA, 2004
A chemical science officer ensures with his know-how, his experience based on continuous improvement and with the help of databases, optimal advice to the operational crew. In the event of incidents with hazardous materials, great attention must
Stephan Rönninger, Thomas Glarner
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity

MedComm
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In the clinical realm, platinum‐based drugs hold an important role in the chemotherapy of CRC.
Wei Li, Chuanyu Yang, Zhuo Cheng, Yuanyuan Wu, Sihan Zhou, Xiaowei Qi, Yi Zhang, Jinhui Hu, Mingjin Xie, Ceshi Chen   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Extracellular Matrix Sulfation in the Tumor Microenvironment Stimulates Cancer Stemness and Invasiveness

Advanced Science
Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kinase (RTK ...
Alican Kuşoğlu, Deniz Örnek, Aslı Dansık, Ceren Uzun, Sena Nur Özkan, Sevgi Sarıca, Kardelen Yangın, Şevval Özdinç, Duygu Turan Sorhun, Nuriye Solcan, Efe Can Doğanalp, Øystein Arlov, Katherine Cunningham, Ismail C. Karaoğlu, Seda Kizilel, Ihsan Solaroğlu, Pınar Bulutay, Pınar Fırat, Suat Erus, Serhan Tanju, Şükrü Dilege, Gordana Vunjak‐Novakovic, Nurcan Tuncbag, Ece Öztürk   +23 more
doaj   +1 more source

Quantifying the uncertainties of chemical evolution studies. II. Stellar yields [PDF]

, 2010
This is the second paper of a series which aims at quantifying the uncertainties in chemical evolution model predictions related to the underlying model assumptions.
A. I. Karakas, Akerman, Andrievsky, Andrievsky, Andrievsky, Andrievsky, Andrievsky, Andrievsky, Andrievsky, Arnett, Asplund, Asplund, Bahcall, Baumüller, Baumüller, Bensby, Bensby, Bensby, Bergemann, Bergemann, Bihain, Bonifacio, Boothroyd, Caffau, Carigi, Carigi, Casagrande, Cayrel, Cescutti, Cescutti, Chiappini, Chiappini, Chiappini, Chiappini, Chieffi, Chiosi, D. Romano, de Jager, Decressin, Dray, Dray, Edmunds, Edvardsson, Ekström, F. Matteucci, Fabbian, Feltzing, François, Fröhlich, Gehren, Giovagnoli, Girardi, Goswami, Gratton, Grevesse, Groenewegen, Hauschildt, Henry, Hirschi, Hirschi, Hoffmeister, Honda, Iben, Israelian, Ivanova, Iwamoto, Iwamoto, Izzard, Karakas, Karakas, Karakas, Karakas, Kobayashi, Kovtyukh, Kroupa, Kudritzki, Lai, Limongi, Luck, Luck, M. Tosi, Maeder, Marcolini, Marigo, Marigo, Mashonkina, Matteucci, Matteucci, Matteucci, Matteucci, McWilliam, Meynet, Meynet, Mishenina, Nakamura, Nissen, Nissen, Nissen, Nomoto, Ohkubo, Portinari, Pumo, Ramírez, Reddy, Reddy, Reimers, Renzini, Romano, Romano, Romano, Romano, Russell, Scalo, Schaller, Shi, Shi, Siess, Spite, Straniero, Takeda, Timmes, Tinsley, Tinsley, Tosi, Umeda, Umeda, van den Hoek, Vassiliadis, Ventura, Ventura, Wallerstein, Woosley, Yoshida, Zhang   +133 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Classification of Current Experimental Models of Epilepsy

Brain Sciences
Introduction: This article provides an overview of several experimental models, including in vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models, that have been employed to investigate epileptogenesis. The present
Carmen Rubio, Héctor Romo-Parra, Alejandro López-Landa, Moisés Rubio-Osornio   +3 more
doaj   +1 more source

Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

BMC Veterinary Research, 2019
Background Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread and has serious consequence, thereby causing significant economic losses in the swine industry worldwide.
Yi Hu, Xiong Cai, Yang Zhan, Xiaomin Yuan, Tanbin Liu, Lei Tan, Yalan Li, Lijie Zhang, Lingchen Yang, Wei Liu, Zhibang Deng, Naidong Wang, Yi Yang, Shiyin Guo, Aibing Wang   +14 more
doaj   +1 more source