Results 51 to 60 of about 1,158,124 (312)

Classification of Current Experimental Models of Epilepsy

Brain Sciences
Introduction: This article provides an overview of several experimental models, including in vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models, that have been employed to investigate epileptogenesis. The present
Carmen Rubio, Héctor Romo-Parra, Alejandro López-Landa, Moisés Rubio-Osornio   +3 more
doaj   +1 more source

Neural Scaling of Deep Chemical Models

, 2022
Massive scale, both in terms of data availability and computation, enables significant breakthroughs in key application areas of deep learning such as natural language processing (NLP) and computer vision.
Ryan, Soklaski, Siddharth, Samsi, Vijay, Gadepally, Simon, Axelrod, Connor, Coley, Nathan, Frey, Rafael, Gomez-Bombarelli   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

BMC Veterinary Research, 2019
Background Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread and has serious consequence, thereby causing significant economic losses in the swine industry worldwide.
Yi Hu, Xiong Cai, Yang Zhan, Xiaomin Yuan, Tanbin Liu, Lei Tan, Yalan Li, Lijie Zhang, Lingchen Yang, Wei Liu, Zhibang Deng, Naidong Wang, Yi Yang, Shiyin Guo, Aibing Wang   +14 more
doaj   +1 more source

Robust constraints on average radial lower mantle anisotropy and consequences for composition and texture [PDF]

, 2015
Seismic anisotropy has been observed in the upper mantle (
de Wit, R. W L, Seismology, Trampert, J., NWO-TOP grant: Probabilistic tomography: from seismic waveforms to thermo-chemical models using neural networks   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Chemical transport model ozone simulations for spring 2001 over the western Pacific : comparisons with TRACE-P lidar, ozonesondes, and Total Ozone Mapping Spectrometer columns [PDF]

, 2003
Two closely related chemical transport models (CTMs) employing the same high-resolution meteorological data (similar to180 km x similar to180 km x similar to600 m) from the European Centre for Medium-Range Weather Forecasts are used to simulate the ozone
Isaksen, I S A, Wild, Oliver, Prather, M J, Oltmans, S J, Sundet, JK, Oltmans, S. J., Sundet, J K, Browell, E. V., Prather, MJ, Browell, E V, Oltmans, SJ, Wild, O, Akimoto, H, Sundet, J. K., Isaksen, ISA, Browell, EV, Prather, M. J., Isaksen, I. S. A., Akimoto, H.   +18 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

“As close as it gets to the truth”: University students’ views on science and scientific models of chemical bonding

Nordic Journal of STEM Education
Distrust of science is a societal concern that could be linked to a limited understanding about the nature of science. Scientific models have an essential role as both tools for doing science and for describing and communicating science.
Iselin Grav Aakre
doaj   +1 more source

Learning from Failure: Predicting Electronic Structure Calculation Outcomes with Machine Learning Models

, 2019
High-throughput computational screening for chemical discovery mandates the automated and unsupervised simulation of thousands of new molecules and materials.
Chenru Duan (5646764), Aditya Nandy (5646765), Jon Paul Janet (3367922), Aditya Nandy (4854412), Kulik, Heather Janine, Duan, Chenru, Heather J. Kulik (1373331), Heather Kulik (4527895), Fang Liu (6251495), Chenru Duan, Chenru Duan (5831468), Fang Liu, Heather J. Kulik, Jon Paul Janet (5646766), Janet, Jon Paul, Aditya Nandy, Jon Paul Janet, Nandy, Aditya, Liu, Fang, Fang Liu (13271)   +19 more
core   +1 more source