Results 41 to 50 of about 12,735,429 (294)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
High School Students’ Mental Models on Chemical Equilibrium
Jurnal Pendidikan Sains, 2019 : Chemical equilibrium knowledge has many abstract concepts that often lead to alternative conceptions and misconceptions. One way that can be used to find out students’ conceptions is to identify their mental models.The purpose of this study was to ...
Hilya Ulinnaja +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Prediction of Chemical Reactions Using Statistical Models of Chemical Knowledge [PDF]
, 2018 Is chemistry discoverable or can it only be invented? – this is the question of a computer scientist and a philosopher of science when looking at application of artificial intelligence methods for developing new chemical entities and new chemical ...
Philipp-Maximilian, Jacob +1 more
core +1 more source
Classification of Current Experimental Models of Epilepsy
Brain SciencesIntroduction: This article provides an overview of several experimental models, including in vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models, that have been employed to investigate epileptogenesis. The present
Carmen Rubio +3 more
doaj +1 more source
BMC Veterinary Research, 2019 Background Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread and has serious consequence, thereby causing significant economic losses in the swine industry worldwide.
Yi Hu +14 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On the Concept of a Chemical Model
Croatica Chemica Acta, 1997 The concepts of model and modeling are discussed. Various classifications of models are given. It is pointed out that the progress of science in general and chemistry in particular is based on models and modeling since no better tools have yet been found to study Nature.
Trinajstić, Nenad, Nikolić, Sonja
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Nordic Journal of STEM EducationDistrust of science is a societal concern that could be linked to a limited understanding about the nature of science. Scientific models have an essential role as both tools for doing science and for describing and communicating science.
Iselin Grav Aakre
doaj +1 more source