Results 291 to 300 of about 25,628,644 (319)
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Characteristics of genetic epidemiology and genetic models for vitiligo
Journal of the American Academy of Dermatology, 2004Vitiligo occurs with a frequency of 0.1% to 2% in various populations and is classified into several subtypes by its clinical presentation. Although genetic factors are thought to be involved in the cause of vitiligo, the genetic models for different phenotypes of vitiligo are unknown.Our purpose was to explore potential genetic models for different ...
Jin-Xian Li +11 more
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2014
Genetic animal models have a long history of contribution to the understanding of alcohol dependence. Studies have provided insight into genetic contributions to risk and are beginning to be used to suggest better targeted pharmacotherapies. This review discusses how different species and genetic methods have been used to target specific aspects of ...
John C. Crabbe, Tamara J. Phillips
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Genetic animal models have a long history of contribution to the understanding of alcohol dependence. Studies have provided insight into genetic contributions to risk and are beginning to be used to suggest better targeted pharmacotherapies. This review discusses how different species and genetic methods have been used to target specific aspects of ...
John C. Crabbe, Tamara J. Phillips
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Adapting genetic regulatory models by genetic programming
Biosystems, 2004In this paper, we focus on the task of adapting genetic regulatory models based on gene expression data from microarrays. Our approach aims at automatic revision of qualitative regulatory models to improve their fit to expression data. We describe a type of regulatory model designed for this purpose, a method for predicting the quality of such models ...
Roger Eriksson, Björn Olsson
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Genetic Programming in Economic Modelling
2005 IEEE Congress on Evolutionary Computation, 2005Typically, economists develop models by first selecting a model structure based on theoretical considerations and equilibrium conditions, followed by parameter estimation from available data. As more and more data become available about economic processes, the question arises whether it is possible to obtain models in which "data speak for themselves",
Uzay Kaymak, K. Duyvesteyn
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Some Models of Genetic Selection
Biometrics, 1979This paper begins with a description of the classical theory of viability selection in which probabilities that individuals of various genotypes survive are in proportions that do not change with time and are independent of population structure. Salient features of viability selection with one and two loci are reviewed.
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Genetic modeling of feed intake
Journal of Animal Science, 2015ABSTRACT With the development of automatic self-feeders and electronic identification, automated, repeated measurements of individual feed intake (FI) and BW are becoming available in more species. Consequently, genetic models for longitudinal data need to be applied to study FI or related traits.
David, Ingrid +4 more
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Organoids for Modeling Genetic Diseases
2018In less than a decade, organoid systems have emerged as an innovative and valid in vitro method to mimic in vivo pathophysiology. Organoids are 3D structures constituted by multiple organ-specific cell types that self-organize and can function as miniature organs. Organoids have quickly become an important tool for basic and translational research with
Perez-Lanzon M. +2 more
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Genetic rodent models of depression
Current Opinion in Pharmacology, 2007Are there appropriate rodent models for human depressive disorders? A model that targets a core aspect of depression can become a helpful tool in the analysis of the causes, genetic or environmental, that result in symptoms homologous to those of depressed patients.
El Yacoubi, Malika, Vaugeois, Jean-Marie
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2019
Both genetic variation and environmental exposures play key roles in the development of mental health or psychopathology. Their roles are interdependent: The effects of genetic variants depend on environment, and the impact of environment depends on the genetic variants.
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Both genetic variation and environmental exposures play key roles in the development of mental health or psychopathology. Their roles are interdependent: The effects of genetic variants depend on environment, and the impact of environment depends on the genetic variants.
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Risk models in genetic epidemiology
Statistical Methods in Medical Research, 2000Advances in the identification and treatment of genetically transmitted diseases have lead to an increased need for reliable estimates of genetic susceptibility risk. These estimates are used in clinic settings to identify individuals at increased risk of being a carrier of a disease susceptibility allele as well as to define the probability of ...
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