Results 71 to 80 of about 158,650 (268)

Time-varying Multi-regime Models Fitting by Genetic Algorithms [PDF]

Many time series exhibit both nonlinearity and nonstationarity. Though both features have often been taken into account separately, few attempts have been proposed to model them simultaneously.
Mattheos Protopapas, Francesco Battaglia
core  

Genetic Animal Models of Cardiovascular Pathologies

This review critically examines the evolving landscape of genetic animal models for investigating cardiovascular diseases (CVDs). We analyze established models, including spontaneously hypertensive rats, Watanabe hyperlipidemic rabbits, etc., and ...
Yulia Silaeva, Andrey Mozhaev, Sergei Syatkin, Vsevolod Belousov, Mikhail Blagonravov, Anna Ryabinina, Vera Ovechkina, Enzo Agostinelli, Ruslan Karpov, Maxim Filatov   +9 more
core   +1 more source

Stochastic models for regulatory networks of the genetic toggle switch

, 2006
Bistability arises within a wide range of biological systems from the λ phage switch in bacteria to cellular signal transduction pathways in mammalian cells. Changes in regulatory mechanisms may result in genetic switching in a bistable system. Recently,
Tian, TH, Tian, Tianhai, Burrage, Kevin, Tian, T., Burrage, K, Burrage, K.   +5 more
core   +1 more source

Comparison of Genetic Susceptibility to Coronary Heart Disease in the Hungarian Populations: Risk Prediction Models for Coronary Heart Disease

, 2023
Background and Aim: It was evaluated whether the integration of genetic risk scores (GRS-unweighted, wGRS-weighted) into conventional risk factor (CRF) models for coronary heart disease or acute myocardial infarction (CHD/AMI) could improve the ...
János Sándor, Ádány, Róza, Róza Ádány, Szilvia Fiatal, Beáta Soltész, Fiatal, Szilvia, Soltész, Beáta, Nayla Nasr, Sándor, János, Nasr, Nayla Mohamed Gomaa   +9 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Extraordinary diversity of antiviral immune-related gene families across 38 bat species

BMC Biology
Background Despite harboring diverse pathogenic viruses, bats rarely exhibit clinical symptoms of the diseases. Previous research has reported evolutionary characteristics in key antiviral gene families in bats, such as natural killer cell receptors, MHC
Guangshuai Liu, Yingying Ren, Shengyang Zhou, Qinyang Hua, Peng Chen, Honghai Zhang, Zhen Liu   +6 more
doaj   +1 more source

Evolving concurrent Petri net models of epistasis

, 2010
A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The primary headaches: genetics, epigenetics and a behavioural genetic model [PDF]

The Journal of Headache and Pain, 2008
The primary headaches, migraine with (MA) and without aura (MO) and cluster headache, all carry a substantial genetic liability. Familial hemiplegic migraine (FHM), an autosomal dominant mendelian disorder classified as a subtype of MA, is due to mutations in genes encoding neural channel subunits. MA/MO are considered multifactorial genetic disorders,
openaire   +2 more sources

Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling

Nature Communications
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory.
Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao   +13 more
doaj   +1 more source