Results 91 to 100 of about 1,458,211 (268)

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

Nature Communications
Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates.
Juan Meng, Cheng Chen, Zhiyong Zhu, Yongkang Sun, Yiming Huang, Kaijie Hu, Jiqiang Fu, Luyan Wu, Ling Li, Yiqin Bai, Tianyi Fei, Zhen Liu, Chao Li, Zhiming Shen, Longqi Liu, Chengyu Li, Tao Song, Cirong Liu, Muming Poo, Shiping Liu, Ying Lei, Yidi Sun   +21 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements

Nature Communications
Chromosome rearrangements may distort 3D chromatin architectures and thus change gene regulation, yet how 3D chromatin structures evolve in insects is largely unknown.
Botong Zhou, Ping Hu, Guichun Liu, Zhou Chang, Zhiwei Dong, Zihe Li, Yuan Yin, Zunzhe Tian, Ge Han, Wen Wang, Xueyan Li   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Centromeric tandem repeats expansions in plateau zokor enhance chromosome stability for high-altitude adaptation

Genome Biology
Background Repetitive elements constitute nearly 50% of mammalian genomes; however, their roles in adaptive evolution remain poorly understood. Their identification and assembly, particularly for tandem repeats, are technically challenging, leading to ...
Zhen-Long Wang, Lu-Ye Shi, Xiu-Yun Liu, Xiao-Qing Yao, Meng-Yang Li, Qiang-Hui Wang, Hao Wu, Hui-Sheng Gong, Liu-Yang Fu, Gang Chang, Li-Xin Wei, Wen-Hui Nie, Wei-Ting Su, Bo Zhao, Tao Zhang, Peng Shi   +15 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics

Nature Communications
Arousal states dynamically shape brain function and behavioral performance, as posited by the Yerkes-Dodson law. Yet, functional network substrates underlying this inverted U-shaped pattern remain unknown.
Chuanjun Tong, Weishuai Li, Yijuan Zou, Ying Xia, Mengchao Pei, Kaiwei Zhang, Yichao Luo, Zhifeng Liang   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The howler monkey genome provides new insights into the distinctive howling and folivorous adaptations of New World monkeys

Genome Biology
Background New World monkeys (Platyrrhini), a highly diverse primate lineage endemic to Mexico, Central and South America, include howler monkeys (Alouatta spp.), one of the most ecologically successful genera in the region.
Ningyawen Liu, Xinglong Zhang, Jin-Jin Zhang, Yong-Xuan Chen, Xiao-Lin Zhuang, Sheng Wang, Yi-Zheng Lu, David N. Cooper, Wu Chen, Meng-Ting Luo, Tai-Cheng Zhou, Michael Hiller, Dong-Dong Wu   +12 more
doaj   +1 more source

Comparative Phylogeography of Two Specialist Rodents in Forest Fragments in Kenya

Life
The fragmented forests of the Kenya highlands, known for their exceptional species richness and endemism, are among the world’s most important biodiversity hotspots. However, detailed studies on the fauna of these ecosystems—especially specialist species
Alois Wambua Mweu, Kenneth Otieno Onditi, Laxman Khanal, Simon Musila, Esther Kioko, Xuelong Jiang   +5 more
doaj   +1 more source