Results 101 to 110 of about 158,650 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

Nature Communications
Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates.
Juan Meng, Cheng Chen, Zhiyong Zhu, Yongkang Sun, Yiming Huang, Kaijie Hu, Jiqiang Fu, Luyan Wu, Ling Li, Yiqin Bai, Tianyi Fei, Zhen Liu, Chao Li, Zhiming Shen, Longqi Liu, Chengyu Li, Tao Song, Cirong Liu, Muming Poo, Shiping Liu, Ying Lei, Yidi Sun   +21 more
doaj   +1 more source

Comparative Phylogeography of Two Specialist Rodents in Forest Fragments in Kenya

Life
The fragmented forests of the Kenya highlands, known for their exceptional species richness and endemism, are among the world’s most important biodiversity hotspots. However, detailed studies on the fauna of these ecosystems—especially specialist species
Alois Wambua Mweu, Kenneth Otieno Onditi, Laxman Khanal, Simon Musila, Esther Kioko, Xuelong Jiang   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements

Nature Communications
Chromosome rearrangements may distort 3D chromatin architectures and thus change gene regulation, yet how 3D chromatin structures evolve in insects is largely unknown.
Botong Zhou, Ping Hu, Guichun Liu, Zhou Chang, Zhiwei Dong, Zihe Li, Yuan Yin, Zunzhe Tian, Ge Han, Wen Wang, Xueyan Li   +10 more
doaj   +1 more source

Equilibrium and non-equilibrium concepts in forest genetic modelling: population- and individually-based approaches

, 2010
The environment is changing and so are forests, in their functioning, in species composition, and in the species’ genetic composition. Many empirical and process-based models exist to support forest management.
Kramer, K., Werf, D.C., van der
core  

Genetic Mouse Models of Neurodegenerative Diseases

Neurodegenerative diseases are generally characterized by the selective degeneration of particular neuronal populations and the accumulation of abnormal or aggregated proteins within, but occasionally external to, neurons in affected brain regions. These
Moore, Darren J., Trancikova, Alzbeta, Ramonet, David   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics

Nature Communications
Arousal states dynamically shape brain function and behavioral performance, as posited by the Yerkes-Dodson law. Yet, functional network substrates underlying this inverted U-shaped pattern remain unknown.
Chuanjun Tong, Weishuai Li, Yijuan Zou, Ying Xia, Mengchao Pei, Kaiwei Zhang, Yichao Luo, Zhifeng Liang   +7 more
doaj   +1 more source

Hide-in-Bird Pond: A new pathway to synergize biodiversity conservation and sustainable development in China

Avian Research
Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch. Although ecotourism is widely promoted as a strategy capable of delivering both environmental and developmental benefits, empirical
Lin He, Dao Yan, Ming Liu, Yuanfang Hu, Shunyu Yao, Fei Wu   +5 more
doaj   +1 more source