Results 121 to 130 of about 158,650 (268)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Unravelling spatial scale effects on elevational diversity gradients: insights from montane small mammals in Kenya

BMC Ecology and Evolution
Background Montane ecosystems play crucial roles as global biodiversity hotspots. However, climatic changes and anthropogenic pressure increasingly threaten the stability of montane community dynamics, such as diversity-elevation interactions, creating a
Kenneth Otieno Onditi, Noé U. de la Sancha, Simon Musila, Esther Kioko, Xuelong Jiang   +4 more
doaj   +1 more source

Development of a progressive HIV-1-Like infection model in northern pig-tailed macaques using stHIV-1sv/G53D

Emerging Microbes and Infections
Simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infections in nonhuman primates closely approximate human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), but intrinsic viral differences limit ...
Tian-Zhang Song, Qing Li, Li-Rong Zhang, Yan Hu, Ying Lu, Yong-Tang Zheng   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

NPC1 promotes HTNV replication by controlling innate immune response

Frontiers in Immunology
Hantaan virus (HTNV) causes the majority of hemorrhagic fever with renal syndrome (HFRS) across Asia, which imposes a substantial public health burden. Virus–host interaction, particularly protein–protein interactions, essentially determined the clinic ...
Hansong Qi, Yuechun Wu, Yuechun Wu, Rong Wei, Rong Wei, Shengyao Chen, Jumin Zhou, Wei Hou, Xinglou Yang   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Perspective on using non-human primates in Exposome research

Ecotoxicology and Environmental Safety
The physiological and pathological changes in the human body caused by environmental pressures are collectively referred to as the Exposome. Human society is facing escalating environmental pollution, leading to a rising prevalence of associated diseases,
Qiu Tu, Gaojing Liu, Xiuyun Liu, Jiao Zhang, Wenxian Xiao, Longbao Lv, Bo Zhao   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Genetic Generalized Additive Models

CoRR
Accepted to NAFIPS ...
Kaaustaaub Shankar, Kelly Cohen
openaire   +2 more sources

Statistical Genetic Approaches to Investigate Genotype-by-Environment Interaction: Review and Novel Extension of Models

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and ...
Sarah Williams-Blangero, Diego, Vincent P., David Ortiz, Marcio Almeida, Eron G. Manusov, Vincent P. Diego, Sandra Laston, Laston, Sandra, Ortiz, David, Manusov, Eron G., John Blangero, Blangero, John, Williams-Blangero, Sarah, Almeida, Marcio   +13 more
core   +1 more source