Results 121 to 130 of about 28,946,101 (334)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma

BMC Medicine
Background Cholangiocarcinoma (CCA) remains a highly lethal malignancy with a dismal prognosis, primarily driven by therapeutic resistance. A dominant resistance mechanism involves overexpression of anti-apoptotic BCL-2 proteins (BCL-XL, BCL-2, MCL-1 ...
Qinghua Zeng, Yan Zhang, Yiwen Yang, Xin Liu, Xin Dong, Yongzhang Pan, Li Hu, Ao Zhang, Jian Yang, Qiuni Luo, Xiang Lai, Guoping Zhu, Xuan Zhang, Yonghan He   +13 more
doaj   +1 more source

Deep generative models of genetic variation capture the effects of mutations

Nature Methods, 2018
Adam J. Riesselman, John Ingraham, D. Marks   +2 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

YTHDF1/RNF7/p27 axis promotes prostate cancer progression

Cell Death and Disease
Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling ...
Yulin Shi, Baiyang Liu, Yong Zhang, Sen Zhao, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng, Cuiping Yang, Yongbin Chen   +11 more
doaj   +1 more source

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2Research in context

EBioMedicine
Summary: Background: Coronavirus disease 2019 (COVID-19) is an immune-related disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The complete pathogenesis of the virus remains to be determined.
Ling Xu, Dandan Yu, Min Xu, Yamin Liu, Lu-Xiu Yang, Qing-Cui Zou, Xiao-Li Feng, Ming-Hua Li, Nengyin Sheng, Yong-Gang Yao   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets

MedComm
Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses.
Ayesha Nisar, Sawar Khan, Wen Li, Li Hu, Priyadarshani Nadeeshika Samarawickrama, Naheemat Modupeola Gold, Meiting Zi, Sardar Azhar Mehmood, Jiarong Miao, Yonghan He   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

Genome Biology
Background Understanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recombination remains poorly understood
Shao-Jie Zhang, Jilong Ma, Meritxell Riera, Søren Besenbacher, Julia E. Niskanen, Noora Salokorpi, Sruthi Hundi, Marjo K. Hytönen, Tong Zhou, Gui-Mei Li, Elaine A. Ostrander, Mikkel Heide Schierup, Hannes Lohi, Guo-Dong Wang   +13 more
doaj   +1 more source