Results 121 to 130 of about 1,516,599 (318)

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

Centromeric tandem repeats expansions in plateau zokor enhance chromosome stability for high-altitude adaptation

Genome Biology
Background Repetitive elements constitute nearly 50% of mammalian genomes; however, their roles in adaptive evolution remain poorly understood. Their identification and assembly, particularly for tandem repeats, are technically challenging, leading to ...
Zhen-Long Wang, Lu-Ye Shi, Xiu-Yun Liu, Xiao-Qing Yao, Meng-Yang Li, Qiang-Hui Wang, Hao Wu, Hui-Sheng Gong, Liu-Yang Fu, Gang Chang, Li-Xin Wei, Wen-Hui Nie, Wei-Ting Su, Bo Zhao, Tao Zhang, Peng Shi   +15 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Integrating Genetic Algorithms and Language Models for Enhanced Enzyme Design [PDF]

Enzymes are molecular machines optimized by nature to allow otherwise impossible chemical processes to occur. Their design is a challenging task due to the complexity of the protein space and the intricate relationships between sequence, structure, and ...
Yves Gaetan, Nana Teukam, Matteo, Manica, Teodoro, Laino, Francesca, Grisoni, Federico, Zipoli, Emanuele, Criscuolo   +5 more
core   +1 more source

Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics

Nature Communications
Arousal states dynamically shape brain function and behavioral performance, as posited by the Yerkes-Dodson law. Yet, functional network substrates underlying this inverted U-shaped pattern remain unknown.
Chuanjun Tong, Weishuai Li, Yijuan Zou, Ying Xia, Mengchao Pei, Kaiwei Zhang, Yichao Luo, Zhifeng Liang   +7 more
doaj   +1 more source

Hide-in-Bird Pond: A new pathway to synergize biodiversity conservation and sustainable development in China

Avian Research
Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch. Although ecotourism is widely promoted as a strategy capable of delivering both environmental and developmental benefits, empirical
Lin He, Dao Yan, Ming Liu, Yuanfang Hu, Shunyu Yao, Fei Wu   +5 more
doaj   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

Spatiotemporal patterns of genetic variation for growth and fertility in Scots pine [PDF]

, 2011
Genetic testing plays an important role in tree breeding. Understanding basic genetic parameters for growth and fertility is a prerequisite for developing a successful breeding strategy to balance between short- and long-term gains.
Kroon, Johan
core  

Comprehensive evaluation and guidance of structural variation detection tools in chicken whole genome sequence data

BMC Genomics
Background Structural variations (SVs) are widespread across genome and have a great impact on evolution, disease, and phenotypic diversity. Despite the development of numerous bioinformatic tools, commonly referred to as SV callers, tailored for ...
Cheng Ma, Xian Shi, Xuzhen Li, Ya-Ping Zhang, Min-Sheng Peng   +4 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source