Results 111 to 120 of about 1,516,599 (318)

Prediction of breeding values and selection responses with genetic heterogeneity of environmental variance [PDF]

, 2007
There is empirical evidence that genotypes differ not only in mean, but also in environmental variance of the traits they affect. Genetic heterogeneity of environmental variance may indicate genetic differences in environmental sensitivity.
Mulder, H. A., H. A. Mulder, W. G. Hill, Mulder, H.A., Hill, W. G., Bijma, P., Hill, W.G., P. Bijma   +7 more
core   +1 more source

The effects of runs-of-homozygosity on pig domestication and breeding

BMC Genomics
Background Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs.
Lin Tao, Hang Liu, Adeniyi C. Adeola, Hai-Bing Xie, Shu-Tang Feng, Ya-Ping Zhang   +5 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Genetic programming in data mining for drug discovery [PDF]

, 2004
Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core  

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Stochastic Models in Population Genetics: Genealogy and Genetic Differentiation in Structured Populations [PDF]

, 1994
PhDThe theory of probability and stochastic processes is applied to a current issue in population genetics, namely that of genealogy and genetic differentiation in subdivided populations.
Herbots, Hilde Maria Jozefa Dominiek
core  

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

Nature Communications
Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates.
Juan Meng, Cheng Chen, Zhiyong Zhu, Yongkang Sun, Yiming Huang, Kaijie Hu, Jiqiang Fu, Luyan Wu, Ling Li, Yiqin Bai, Tianyi Fei, Zhen Liu, Chao Li, Zhiming Shen, Longqi Liu, Chengyu Li, Tao Song, Cirong Liu, Muming Poo, Shiping Liu, Ying Lei, Yidi Sun   +21 more
doaj   +1 more source

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source

Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements

Nature Communications
Chromosome rearrangements may distort 3D chromatin architectures and thus change gene regulation, yet how 3D chromatin structures evolve in insects is largely unknown.
Botong Zhou, Ping Hu, Guichun Liu, Zhou Chang, Zhiwei Dong, Zihe Li, Yuan Yin, Zunzhe Tian, Ge Han, Wen Wang, Xueyan Li   +10 more
doaj   +1 more source

Comparative Phylogeography of Two Specialist Rodents in Forest Fragments in Kenya

Life
The fragmented forests of the Kenya highlands, known for their exceptional species richness and endemism, are among the world’s most important biodiversity hotspots. However, detailed studies on the fauna of these ecosystems—especially specialist species
Alois Wambua Mweu, Kenneth Otieno Onditi, Laxman Khanal, Simon Musila, Esther Kioko, Xuelong Jiang   +5 more
doaj   +1 more source