Results 111 to 120 of about 158,650 (268)

Genetic and Environmental Influences on Female Sexual Orientation, Childhood Gender Typicality and Adult Gender Identity

, 2011
BACKGROUND: Human sexual orientation is influenced by genetic and non-shared environmental factors as are two important psychological correlates--childhood gender typicality (CGT) and adult gender identity (AGI).
Rahman Qazi, Rahman, Qazi; id_orcid, Spector, T, Qazi Rahman, Cherkas, L, Burri Andrea, Burri, A, Rahman, Q, Timothy Spector, Cherkas, Lynn, Lynn Cherkas, Burri, Andrea, Spector, Timothy, Cherkas Lynn, Andrea Burri, Spector Timothy   +15 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comprehensive evaluation and guidance of structural variation detection tools in chicken whole genome sequence data

BMC Genomics
Background Structural variations (SVs) are widespread across genome and have a great impact on evolution, disease, and phenotypic diversity. Despite the development of numerous bioinformatic tools, commonly referred to as SV callers, tailored for ...
Cheng Ma, Xian Shi, Xuzhen Li, Ya-Ping Zhang, Min-Sheng Peng   +4 more
doaj   +1 more source

Genetic Drift in Genetic Algorithm Selection Schemes

, 1999
A method for calculating genetic drift in terms of changing population fitness variance is presented. The method allows for an easy comparison of different selection schemes and exact analytical results are derived for traditional generational selection,
Prügel-Bennett, A., Rogers, A.
core  

Runaway sexual selection without genetic correlations : social environments and flexible mate choice initiate and enhance the Fisher process

, 2012
Female mating preferences are often flexible, reflecting the social environment in which they are expressed. Associated indirect genetic effects (IGEs) can affect the rate and direction of evolutionary change, but sexual selection models do not capture ...
Moore, Allen J., Bailey, Nathan William, Nathan W. Bailey, Allen J. Moore   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Social communicative characteristics of adolescent police dogs: Acquired experience plays a crucial role

Animal Cognition
The domestic dog is known for its strong ability to respond to human social cues. However, conclusions based on highly socialized dogs may not generalize to all populations since acquired experience is known to greatly influence canine cognition.
Xinyu Huang, Xisheng Mei, Kui Wan, Chao Chen, Lu Wang, Xiaoyang Wang, Guo-Dong Wang   +6 more
doaj   +1 more source

The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

eLife
The spatial and temporal linear expression of Hox genes establishes a regional Hox code, which is crucial for the antero-posterior (A-P) patterning, segmentation, and neuronal circuit development of the hindbrain.
Huishan Wang, Xingyan Liu, Yamin Liu, Chencheng Yang, Yaxin Ye, Xiaomei Yu, Nengyin Sheng, Shihua Zhang, Bingyu Mao, Pengcheng Ma   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Spatiotemporal patterns of genetic variation for growth and fertility in Scots pine [PDF]

, 2011
Genetic testing plays an important role in tree breeding. Understanding basic genetic parameters for growth and fertility is a prerequisite for developing a successful breeding strategy to balance between short- and long-term gains.
Kroon, Johan
core