Results 111 to 120 of about 1,458,211 (268)
Transcriptome of fetal cortex of tree shrew underlying the emergence of outer subventricular zone
Communications BiologyA defining feature of primates is the expansion and increased complexity of the cerebral cortex, processes that are largely associated with evolutionary adaptations of the neural progenitor-enriched outer subventricular zone (OSVZ).
Ting Hu +6 more
doaj +1 more source
eLifeThe spatial and temporal linear expression of Hox genes establishes a regional Hox code, which is crucial for the antero-posterior (A-P) patterning, segmentation, and neuronal circuit development of the hindbrain.
Huishan Wang +9 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
BMC Ecology and EvolutionBackground Montane ecosystems play crucial roles as global biodiversity hotspots. However, climatic changes and anthropogenic pressure increasingly threaten the stability of montane community dynamics, such as diversity-elevation interactions, creating a
Kenneth Otieno Onditi +4 more
doaj +1 more source
Emerging Microbes and InfectionsSimian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infections in nonhuman primates closely approximate human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), but intrinsic viral differences limit ...
Tian-Zhang Song +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
NPC1 promotes HTNV replication by controlling innate immune response
Frontiers in ImmunologyHantaan virus (HTNV) causes the majority of hemorrhagic fever with renal syndrome (HFRS) across Asia, which imposes a substantial public health burden. Virus–host interaction, particularly protein–protein interactions, essentially determined the clinic ...
Hansong Qi +8 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Perspective on using non-human primates in Exposome research
Ecotoxicology and Environmental SafetyThe physiological and pathological changes in the human body caused by environmental pressures are collectively referred to as the Exposome. Human society is facing escalating environmental pollution, leading to a rising prevalence of associated diseases,
Qiu Tu +6 more
doaj +1 more source