Results 71 to 80 of about 27,132,286 (267)

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Molecular Neurodegeneration
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation.
Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao   +4 more
doaj   +1 more source

Towards a Cure for Diamond–Blackfan Anemia: Views on Gene Therapy

Cells
Diamond–Blackfan anemia (DBA) is a rare genetic disorder affecting the bone marrow’s ability to produce red blood cells, leading to severe anemia and various physical abnormalities.
Matilde Vale, Jan Prochazka, Radislav Sedlacek   +2 more
doaj   +1 more source

Transport of Molecular Motor Dimers in Burnt-Bridge Models

, 2007
Dynamics of molecular motor dimers, consisting of rigidly bound particles that move along two parallel lattices and interact with underlying molecular tracks, is investigated theoretically by analyzing discrete-state stochastic continuous-time burnt ...
Alexander Yu Morozov, Anatoly B Kolomeisky, Artyomov M N, Bray D, Howard J, Lodish H   +5 more
core   +1 more source

Cytoscape: a software environment for integrated models of biomolecular interaction networks.

Genome Research, 2003
Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework.
Paul Shannon, Andrew Markiel, Owen Ozier, N. Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, T. Ideker   +8 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Effects of starter cultures on the metabolite profile, antioxidant activities, and anti-aging properties of tapuy lees

Discover Food
The Philippine rice wine (tapuy) and tapuy lees making process utilizes bubod, the traditional starter culture. The bubod contains variable number and species of microorganisms and influences the physical and chemical properties of tapuy and tapuy lees ...
Edward Kevin B. Bragais, Paul Mark B. Medina   +1 more
doaj   +1 more source

The Global Evolution of Giant Molecular Clouds II: The Role of Accretion [PDF]

, 2011
We present virial models for the global evolution of giant molecular clouds. Focusing on the presence of an accretion flow, and accounting for the amount of mass, momentum, and energy supplied by accretion and star formation feedback, we are able to ...
Abdo, Ballesteros-Paredes, Ballesteros-Paredes, Bigiel, Blitz, Bolatto, Christopher D. Matzner, Christopher F. McKee, Dickel, Engargiola, Evans, Fall, Fukui, Glover, Heiles, Heyer, Heyer, Heyer, Hughes, Imara, Kawamura, Kegel, Kennicutt, Kim, Kim, Kim, Krumholz, Krumholz, Krumholz, Krumholz, Krumholz, Krumholz, Lada, Larson, Leroy, Leroy, Li, Li, Li, Li, Lopez, Mark R. Krumholz, Matzner, Matzner, Matzner, McKee, McKee, McKee, Meynet, Mizuno, Murray, Nathan J. Goldbaum, Onodera, Parravano, Roman-Duval, Rosolowsky, Schaerer, Schlegel, Schruba, Schruba, Stark, Stone, Strong, Tamburro, Tan, Tan, Tasker, Tasker, Thilker, Troland, Vazquez-Semadeni, Vázquez-Semadeni, Wang, Wang, Williams, Wise, Wolfire, Wong, Wong, Yang   +79 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Dynamic Properties of Molecular Motors in Burnt-Bridge Models

, 2007
Dynamic properties of molecular motors that fuel their motion by actively interacting with underlying molecular tracks are studied theoretically via discrete-state stochastic ``burnt-bridge'' models.
Alexander Yu Morozov, Anatoly B Kolomeisky, Bray D, Ekaterina Pronina, Howard J, Lodish H, Maxim N Artyomov, Oshanin G, Oshanin G   +8 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source