Results 201 to 210 of about 1,748,144 (308)

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

Advanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary Davidson, Pavel A. Levkin   +4 more
wiley   +1 more source

Application of multi-feature-based machine learning models to predict neurological outcomes of cardiac arrest

Resuscitation Plus
Cardiac arrest (CA) is a major disease burden worldwide and has a poor prognosis. Early prediction of CA outcomes helps optimize the therapeutic regimen and improve patients’ neurological function. As the current guidelines recommend, many factors can be
Peifeng Ni, Sheng Zhang, Wei Hu, Mengyuan Diao   +3 more
doaj  

Abolish Psychiatry, Abolish Neurology: Toward a Unified Discipline of Brain Medicine. [PDF]

Cureus
Lakhan SE.
europepmc   +1 more source

Enhancing Ultrasound Power Transfer: Efficiency, Acoustics, and Future Directions

Advanced Materials, EarlyView.
Implantable devices significantly enhance healthcare but are limited by battery life. Ultrasound power transfer technology offers a promising solution for sustainable operation. This review addresses gaps in current research, particularly in sound field analysis and energy efficiency optimization.
Yi Zheng, Zhuomin Zhang, Yanhu Zhang, Qiqi Pan, Xiaodong Yan, Xuemu Li, Zhengbao Yang   +6 more
wiley   +1 more source

Explainable machine learning model based on EEG, ECG, and clinical features for predicting neurological outcomes in cardiac arrest patient. [PDF]

Sci Rep
Niu Y, Chen X, Fan J, Liu C, Fang M, Liu Z, Meng X, Liu Y, Lu L, Fan H.   +9 more
europepmc   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Better statistical reporting does not lead to statistical rigour: lessons from two decades of pseudoreplication in mouse-model studies of neurological disorders. [PDF]

Mol Autism
Eleftheriou C, Giachetti S, Hickson R, Kamnioti-Dumont L, Templaar R, Aaltonen A, Tsoukala E, Kim N, Fryer-Petridis L, Henley C, Erdem C, Wilson E, Maio B, Ye J, Pierce JC, Mazur K, Landa-Navarro L, Petrović NG, Bendova S, Woods H, Rizzi M, Salazar-Sanchez V, Anstey N, Asiminas A, Basu S, Booker SA, Harris A, Heyes S, Jackson A, Crocker-Buque A, McMahon AC, Till SM, Wijetunge LS, Wyllie DJ, Abbott CM, O'Leary T, Kind PC.   +36 more
europepmc   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Mitochondrial quality control and transfer communication in neurological disorders and neuroinflammation. [PDF]

Front Immunol
Ma Y, Song R, Duan C.
europepmc   +1 more source

Recent Advances in Stimuli‐Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine

Advanced Materials, EarlyView.
This review explores the integration of responsive materials and soft robotic actuators with implantable electronics to address key challenges in bioelectronic medicine. By enabling shape actuation, these technologies improve deployment, adaptability, and accuracy in minimally invasive procedures.
Chaoqun Dong, George G. Malliaras
wiley   +1 more source