Results 51 to 60 of about 192,740 (318)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Modeling Organizational Architectural Styles in UML [PDF]
, 2003 Today's information systems operate within a dynamic, organizational context and consequently require flexible architectures to ensure that they remain operational and useful. The Tropos software development methodology is founded on the premise that social and intentional concepts (such as those of actor and goal) can be used throughout the ...
J. Castro, C. Silva, Mylopoulos, Ioannis
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Middle managers’ role in organizational commitment and organizational citizenship behaviours [PDF]
, 2015 “Any motivated behavior, either preparatory or consummatory, must be understood to be a channel through which many basic needs may be simultaneously expressed or satisfied.
Landa, Clive H.
core
Gestão & Produção, 2005 Representar, entender e explicar a ação organizacional tem sido tema de muitos estudos e pesquisas. O presente trabalho se une a este esforço, como uma contribuição dentro da Teoria de Gestão de Operações.
Edson Pinheiro de Lima +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Binus Business Review, 2012 This paper develops a conceptual framework for intended study which will examine the role of intrepreneurship in building cultural competitiveness in Higher Education (HE).
Agustinus Dedy Handrimurtjahjo
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Framework for a Dynamic Organizational Memory Information System
, 1999 Organizational memory information systems (OMIS) implement important aspects of organizational memory with the aim of enhancing organizational effectiveness. We propose a 3-layered framework for a dynamic OMIS. The framework consists of a pragmatic layer
Zaslavsky, Arkady +7 more
core +1 more source
Design Science, 2020 In the context of cross-disciplinary and cross-company cooperation, several challenges in developing manufacturing systems are revealed through industrial use cases. To tackle these challenges, two propositions are used in parallel.
Birgit Vogel-Heuser +10 more
doaj +1 more source