Results 231 to 240 of about 5,689,852 (278)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Genetic diversity and population structure of the Taigan dog breed

FEBS Open Bio, EarlyView.
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova, Anastassiya Perfilyeva, Мamura Begmanova, Assel Zhaxylykova, Arailym Yerzhan, Kanagat Yergali, Almazbek Akunov, Marat Munarbek uulu, Anna Khamchukova, Almira Amirgaliyeva, Yelena Kuzovleva   +10 more
wiley   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

FEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa, Yasushi Shigeri, Shingo Fujisaki   +2 more
wiley   +1 more source

Semi‐automated hippocampal avoidance whole‐brain radiotherapy planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Hippocampal avoidance whole‐brain radiotherapy (HA‐WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time‐consuming and may vary in quality, necessitating the development of automated approaches to streamline ...
Dong Joo Rhee, Subha Perni, Kelly J. Perrin, Kevin E. Casey, Alexandra O. Leone, Callistus M. Nguyen, Laurence E. Court, He Wang, Xin Wang, Eun Young Han   +9 more
wiley   +1 more source

Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang, Eric Aliotta, Neelam Tyagi, Paola Godoy Scripes, Nicolas Côté, Ergys Subashi, Qijie Huang, Lian Sun, Ching‐Yun Chan, Angela Ng, Theresa Wunner, Victoria Brennan, Kaveh Zakeri, James Mechalakos   +13 more
wiley   +1 more source

Evaluating feature extraction reproducibility across image biomarker standardization initiative‐compliant radiomics platforms using a digital phantom

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The aim of this study was to thoroughly analyze the reproducibility of radiomics feature extraction across three Image Biomarker Standardization Initiative (IBSI)‐compliant platforms using a digital phantom for benchmarking. It uncovers high consistency among common features while also pointing out the necessity for standardization ...
Han‐Back Shin, Heesoon Sheen, Jang‐Hoon Oh, Young Eun Choi, Kihoon Sung, Hyun Ju Kim   +5 more
wiley   +1 more source

GWAS Procedures for Gene Mapping in Diverse Populations With Complex Structures. [PDF]

Bio Protoc
Zuo Z, Li M, Liu D, Li Q, Huang B, Ye G, Wang J, Tang Y, Zhang Z.   +8 more
europepmc   +1 more source

From agent-based models to statistical emulators

, 2013
Bijak, Jakub, Hilton, Jason, Silverman, Eric   +2 more
core  

LiMMCov: An interactive research tool for efficiently selecting covariance structures in linear mixed models using insights from time series analysis. [PDF]

PLoS One
Savieri P, Stas L, Barbé K.
europepmc   +1 more source