Results 91 to 100 of about 27,750,649 (274)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Correction to: A common gene drive language eases regulatory process and eco-evolutionary extensions

BMC Ecology and Evolution, 2021
Prateek Verma, R. Guy Reeves, Chaitanya S. Gokhale   +2 more
doaj   +1 more source

Identification of models, theoretical design and formal evaluation of integrated specialist community health service provision for the first 2000 days: a protocol for a scoping review. [PDF]

BMJ Open, 2022
Nelson HJ, Munns A, Ong S, Watson L, Burns S.   +4 more
europepmc   +1 more source

Computational studies of biomembrane systems: Theoretical considerations, simulation models, and applications

, 2013
This chapter summarizes several approaches combining theory, simulation and experiment that aim for a better understanding of phenomena in lipid bilayers and membrane protein systems, covering topics such as lipid rafts, membrane mediated interactions ...
Deserno, Markus, Kremer, Kurt, Paulsen, Harald, Peter, Christine, Schmid, Friederike   +4 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Bridging the gap between evidence and policy for infectious diseases: How models can aid public health decision-making

International Journal of Infectious Diseases, 2016
The dominant approach to decision-making in public health policy for infectious diseases relies heavily on expert opinion, which often applies empirical evidence to policy questions in a manner that is neither systematic nor transparent.
Gwenan M. Knight, Nila J. Dharan, Gregory J. Fox, Natalie Stennis, Alice Zwerling, Renuka Khurana, David W. Dowdy   +6 more
doaj   +1 more source

Theoretical constraints for the magnetic-dimer transition in two-dimensional spin models

, 2005
From general arguments, that are valid for spin models with sufficiently short-range interactions, we derive strong constraints on the excitation spectrum across a continuous phase transition at zero temperature between a magnetic and a dimerized phase ...
Federico Becca, J. Zinn-Justin, Leonardo Spanu, Sandro Sorella   +3 more
core   +1 more source

Empowering Online Adult Educators: Integrating Artificial Intelligence for Enhanced Instructional Strategies

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article explores how artificial intelligence (AI) can support online adult learning by aligning with Knowles’ four principles of andragogy: involvement, experience, problem‐centeredness, and relevance. Three activities were analyzed using a comparative case study (CCS) method.
Xi Lin, Steve W. Schmidt
wiley   +1 more source

Theoretical models for duct acoustic propagation and radiation [PDF]

The development of computational methods in acoustics has led to the introduction of analysis and design procedures which model the turbofan inlet as a coupled system, simultaneously modeling propagation and radiation in the presence of realistic ...
Eversman, Walter
core   +1 more source