Results 61 to 70 of about 4,986,787 (248)

Models. Models. Models. So What? [PDF]

, 2009
In 1985, in an interview for some then-popular magazine, I was asked when models and model-driven development would become commonplace. "In three years time", I replied confidently. In 1987, I was asked the same question, and my answer remained the same. And 1989. And '91.
openaire   +1 more source

Computational modelling [PDF]

Current Opinion in Neurobiology, 1994
Computation modelling is playing an increasingly accepted and important role in neuroscience. It is not a unitary enterprise, though, and the distinction between two different sorts of modelling, one interested in description and the other also in function, is illustrated by their application to activity-dependent developmental plasticity and adult ...
openaire   +3 more sources

Isoorientin Promotes Early Porcine Embryonic Development by Alleviating Oxidative Stress and Improving Lipid Metabolism

Animals
Isoorientin (ISO) is a natural lignan glycoside flavonoid found in various plants, including Charcot and Stonecrop. ISO exhibits diverse physiological and pharmacological effects, such as antioxidative, anti-inflammatory, hepatoprotective, antiviral ...
Zilong Meng, Jiajun Ren, Chuman Huang, Huimei Huang, Xiuwen Yuan, Yinghua Li, Nam-Hyung Kim, Yongnan Xu   +7 more
doaj   +1 more source

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

Nature Communications, 2020
Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safety ...
Linyuan Ma, Jinxue Ruan, Jun Song, Luan Wen, Dongshan Yang, Jiangyang Zhao, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Jie Xu   +9 more
doaj   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment

Cancer Cell International
Lysosomes, as crucial organelles within cells, carry out diverse biological functions such as waste degradation, regulation of the cellular environment, and precise control of cell signaling.
Jianlei Bi, Yincong Sun, Meihua Guo, Xiaoxin Sun, Jie sun, Rujiao Jiang, Ning Wang, Gena Huang   +7 more
doaj   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Lack of shared neoantigens in prevalent mutations in cancer

Journal of Translational Medicine
Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint.
Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte, Luigi Buonaguro   +4 more
doaj   +1 more source

SUPERMATRIX MODELS [PDF]

International Journal of Modern Physics A, 1992
Random matrix models based on an integral over supermatrices are proposed as a natural extension of bosonic matrix models. The subtle nature of superspace integration allows these models to have very different properties from the analogous bosonic models. Two choices of integration slice are investigated. One leads to a perturbative structure which is
openaire   +2 more sources

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source