Results 81 to 90 of about 8,909,971 (264)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Models, Probability, and the Deep Past
, 2014 The case of nonidentifiable parameters in divergence time estimates in evolutionary theory offers an interesting example for the study of statistical models.
Pence, Charles H. +1 more
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Rapid synthesis: Innovative models for the delivery of pharmacy services in rural and remote areas
, 2023 An in-depth synthesis of what is known based on the best available global research evidence (i.e., evidence syntheses) and local research evidence (i.e., single studies) and may include a scan of experiences from other countries and from Canadian ...
Ali, A +7 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Context Modeling: Task Model and Practice Model [PDF]
, 2007 Contextual Graphs are a context-based formalism used in various real-world applications. They allow a uniform representation of elements of reasoning and of contexts for describing different human tasks such as troubleshooting and interpretation. A contextual graph represents a task realization.
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Center for Teaching Old Models New Tricks (TOMNET): Data Management Plan (DMP)
This document constitutes a Data Management Plan (DMP) for the Center for Teaching Old Models New Tricks (TOMNET), a US Department of Transportation Tier 1 University Transportation Center (UTC) led by Arizona State University (ASU).
Center for Teaching Old Models New Tricks (TOMNET)
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, 1996 Architects use many types of models to simulate space either in their design process or as final specifications for building them. These models have been proved useful or effective for specific purposes. This paper evaluates architectural models in terms
I. Abbo
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