Results 111 to 120 of about 86,395,692 (257)

Dark Matter Astrophysics

, 2009
These lectures are intended to provide a brief pedagogical review of dark matter for the newcomer to the subject. We begin with a discussion of the astrophysical evidence for dark matter.
Marc Kamionkowski, Kris Sigurdson, Guido D'Amico   +2 more
core  

Millicharged particles from proton bremsstrahlung in the atmosphere

Journal of High Energy Physics
Light millicharged particles can be copiously produced from meson decays in cosmic ray collisions with the atmosphere, leading to detectable signals in large underground neutrino detectors.
Mingxuan Du, Rundong Fang, Zuowei Liu
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Direct detection of electromagnetically interacting ultraheavy dark matter

Journal of High Energy Physics
At a level too faint for astronomy, particle dark matter may interact with Standard Model states via the photon. We derive limits from direct detection experiments on photon-mediated nuclear interactions up to operator dimension-6, viz., via a ...
Jason Kumar, Biprajit Mondal, Girish Muralidhara, Nirmal Raj   +3 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Multicomponent dark matter with collider implications

Journal of High Energy Physics
The present work aims to study an extension of the Standard Model (SM) that addresses the prominent SM shortcomings, i.e., can explain the neutrino mass, the dark matter (DM) content, and the matter-antimatter asymmetry of the Universe.
Laura Covi, Shyamashish Dey, Sarif Khan, Santosh Kumar Rai   +3 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Conformal freeze-in from neutrino portal

Journal of High Energy Physics
We study a scenario where a dark sector, described by a Conformal Field Theory (CFT), interacts with the Standard Model through the neutrino portal. In this setup, conformal invariance breaks below the electroweak scale, causing the theory to transition ...
Sungwoo Hong, Maxim Perelstein, Taewook Youn   +2 more
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source