Results 111 to 120 of about 92,121 (267)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Probing invisible dark photon models via atmospheric collisions

Journal of High Energy Physics
Atmospheric collisions can copiously produce dark sector particles in the invisible dark photon model, leading to detectable signals in underground neutrino detectors.
Mingxuan Du, Rundong Fang, Zuowei Liu, Wenxi Lu, Zicheng Ye   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Unitarization of the Sommerfeld enhancement through the renormalization group

Journal of High Energy Physics
When a pair of dark matter particles interacts via a long-range force mediated by a light particle, their nonrelativistic annihilation cross section can be significantly enhanced — a phenomenon known as the Sommerfeld enhancement.
Yuki Watanabe
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Scattering of non-relativistic finite-size particles and puffy dark matter direct detection

Journal of High Energy Physics
In this work we consider the scattering between non-relativistic particles with different finite sizes. We first calculate their interaction potential and apply the partial wave method to obtain their scattering cross section.
Wu-Long Xu, Jin Min Yang, Jun Zhao
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Asymmetric cannibal dark matter: constraints from neutron star

Journal of High Energy Physics
Asymmetric dark matter can be efficiently captured by neutron stars via elastic scattering with nucleons and dark matter self scattering. The accumulated dark matter thermalizes and concentrates in the stellar interior, forming a dark matter core.
Ujjal Kumar Dey, Sourav Gope
doaj   +1 more source

Dark matter halo formation in the multicomponent dark matter models

, 2013
This work investigates a set of cosmological collisionless N-body simulations with featured power spectra of initial perturbations in the context of the core-cusp and satellites problems. On the studied power spectra some scales of fluctuations were suppressed. Such spectral features can be caused by multicomponent dark matter.
Semenov, Vadim, Pilipenko, Sergey, Doroshkevich, Andrei, Lukash, Vladimir, Mikheeva, Elena   +4 more
openaire   +2 more sources