Results 91 to 100 of about 92,121 (267)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Enhancement of p-wave dark matter annihilation by quasi-bound states

Journal of High Energy Physics
We scrutinize the Sommerfeld enhancement in dark matter pair annihilation for p-wave and higher-ℓ partial waves. For the Yukawa potential these feature a super-resonant Breit-Wigner peak in their velocity-dependence close to Sommerfeld resonances as well
Martin Beneke, Tobias Binder, Lorenzo De Ros, Mathias Garny   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The quintuplet annihilation spectrum

Journal of High Energy Physics
We extend the Effective Field Theory of Heavy Dark Matter to arbitrary odd representations of SU(2) and incorporate the effects of bound states. This formalism is then deployed to compute the gamma-ray spectrum for a 5 of SU(2): quintuplet dark matter ...
Matthew Baumgart, Nicholas L. Rodd, Tracy R. Slatyer, Varun Vaidya   +3 more
doaj   +1 more source

Minimal dark matter: model and results

New Journal of Physics, 2009
We recap the main features of Minimal Dark Matter (MDM) and assess its status in the light of the recent experimental data. The theory selects an electroweak 5-plet with hypercharge Y=0 as a fully successful DM candidate, automatically stable against decay and with no free parameters: DM is a fermion with a 9.6 TeV mass.
Cirelli M, STRUMIA, ALESSANDRO
openaire   +4 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Multicomponent dark matter with collider implications

Journal of High Energy Physics
The present work aims to study an extension of the Standard Model (SM) that addresses the prominent SM shortcomings, i.e., can explain the neutrino mass, the dark matter (DM) content, and the matter-antimatter asymmetry of the Universe.
Laura Covi, Shyamashish Dey, Sarif Khan, Santosh Kumar Rai   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Millicharged particles from proton bremsstrahlung in the atmosphere

Journal of High Energy Physics
Light millicharged particles can be copiously produced from meson decays in cosmic ray collisions with the atmosphere, leading to detectable signals in large underground neutrino detectors.
Mingxuan Du, Rundong Fang, Zuowei Liu
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source