Results 81 to 90 of about 92,121 (267)

An asymmetric SIMP dark matter model

Journal of High Energy Physics, 2022
Abstract In this paper, we construct the first asymmetric strongly interacting massive particles (SIMP) dark matter (DM) model, where a new vector-like fermion and a new complex scalar both having nonzero chemical potentials can be asymmetric DM particles.
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Search for WIMPs at future μ + μ + colliders

Journal of High Energy Physics
Weakly interacting massive particles (WIMPs) with electroweak charges, such as the wino and the Higgsino, stand out as natural candidates for dark matter in the universe. In this paper, we study the search for WIMPs at future multi-TeV μ + μ + colliders.
Hajime Fukuda, Takeo Moroi, Atsuya Niki, Shang-Fu Wei   +3 more
doaj   +1 more source

Simplified models of mixed dark matter [PDF]

Journal of Cosmology and Astroparticle Physics, 2014
We explore simplified models of mixed dark matter (DM), defined here to be a stable relic composed of a singlet and an electroweak charged state. Our setup describes a broad spectrum of thermal DM candidates that can naturally accommodate the observed DM abundance but are subject to substantial constraints from current and upcoming direct detection ...
Cheung, Clifford, Sanford, David
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USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Self-interaction of super-resonant dark matter

Journal of High Energy Physics
The ΛCDM model, while successful on large cosmological scales, faces challenges on small scales. A promising solution posits that dark matter (DM) exhibits strong self-interaction, enhanced through the narrow resonance or Sommerfeld effects.
Shao-Song Tang, Murat Abdughani
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Light in the shadows: primordial black holes making dark matter shine

Journal of High Energy Physics
We consider the possibility of indirect detection of dark sector processes by investigating a novel form of interaction between ambient dark matter (DM) and primordial black holes (PBHs). The basic scenario we envisage is that the ambient DM is “dormant”,
Kaustubh Agashe, Manuel A. Buen-Abad, Jae Hyeok Chang, Steven J. Clark, Bhaskar Dutta, Yuhsin Tsai, Tao Xu   +6 more
doaj   +1 more source

A unified model for inflation and dark matter [PDF]

Journal of Physics A: Mathematical and Theoretical, 2007
We present a model which contains a new complex scalar field $Ψ$, interacting with a new real scalar field, $χ$, and an effective potential whose symmetry is almost exact, being explicitly broken by Planck-scale effects. We study the possibility of relating {\em inflation} with the {\em dark matter} of the universe. We find that for exponentially small
openaire   +3 more sources