Results 81 to 90 of about 86,395,692 (257)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Testing phenomenological Dark Matter models using the Fermi LAT data [PDF]

, 2022
We develop a phenomenological analysis for several candidates of Dark Matter, which will be gorunded in the data provided by the Fermi Gamma Ray Space Telescope (Fermi/LAT).
Piras, Davide
core  

Z ′ portal dark matter with observable ∆N eff

Journal of High Energy Physics
In the conventional Z ′ portal dark matter scenario, the prediction of detectable dark matter χ typically relies on the collider sensitivities of Z ′ and direct detection, where the Majorana type right-handed neutrinos are usually assumed.
Ang Liu, Zhi-Long Han, Fei Huang
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

LHC Dark Matter Working Group: Next-generation spin-0 dark matter models [Elektronisk resurs]

, 2020
Dark matter (DM) simplified models are by now commonly used by the ATLAS and CMS Collaborations to interpret searches for missing transverse energy (ET miss).
Tomohiro, A.,, Zhou, C.,, Lund University., Doglioni, Caterina,, et al.   +4 more
core   +1 more source

Gamma-ray signatures of thermal misalignment dark matter

Journal of High Energy Physics
Thermal misalignment is a viable dark matter scenario where the misalignment of a dark matter scalar, feebly coupled to the Standard Model particles, is generated through thermal effects from the primordial plasma.
Koichi Hamaguchi, Ryoichiro Hayakawa, Hiroki Takahashi   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A radiative neutrino mass model with semi-annihilating boosted dark matter

Journal of High Energy Physics
Boosted dark matter can provide a distinctive signature of a non-minimal dark sector. In this work, we construct a radiative neutrino mass model that allows for the production of boosted dark matter in the present universe through semi-annihilation.
Motoko Fujiwara, Takashi Toma
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Novel Collider Signature for Little Higgs Dark Matter Models

, 2016
Little Higgs models with T -parity provide a stable neutral particle AH, the lightest T -odd particle (LTP), which was recently proposed to explain the cold dark matter of the Universe.
Chen, Chian-Shu;Cheung, Kingman;Yuan, Tzu-Chiang
core   +1 more source