Results 71 to 80 of about 86,395,692 (257)

Light in the shadows: primordial black holes making dark matter shine

Journal of High Energy Physics
We consider the possibility of indirect detection of dark sector processes by investigating a novel form of interaction between ambient dark matter (DM) and primordial black holes (PBHs). The basic scenario we envisage is that the ambient DM is “dormant”,
Kaustubh Agashe, Manuel A. Buen-Abad, Jae Hyeok Chang, Steven J. Clark, Bhaskar Dutta, Yuhsin Tsai, Tao Xu   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enhancement of p-wave dark matter annihilation by quasi-bound states

Journal of High Energy Physics
We scrutinize the Sommerfeld enhancement in dark matter pair annihilation for p-wave and higher-ℓ partial waves. For the Yukawa potential these feature a super-resonant Breit-Wigner peak in their velocity-dependence close to Sommerfeld resonances as well
Martin Beneke, Tobias Binder, Lorenzo De Ros, Mathias Garny   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The cosmological relevance of Fuzzy Dark Matter

, 2023
reservedThe concordance model of cosmology, the so-called Lambda CDM model, shows some shortcomes. However, if the dark matter considered in the model is characterized by an extremely low mass, then some of the imperfection could be explained.
PANOZZO, LUCA
core  

Dark Energy And Life's Ultimate Future [PDF]

, 2006
The discovery of the present accelerated expansion of space changed everything regarding cosmology and life's ultimate prospects. Both the optimistic scenarios of an ever (but decelerated) expanding universe and of a collapsing universe seem to be no ...
Ruediger Vaas, Vaas, Ruediger
core   +1 more source

The quintuplet annihilation spectrum

Journal of High Energy Physics
We extend the Effective Field Theory of Heavy Dark Matter to arbitrary odd representations of SU(2) and incorporate the effects of bound states. This formalism is then deployed to compute the gamma-ray spectrum for a 5 of SU(2): quintuplet dark matter ...
Matthew Baumgart, Nicholas L. Rodd, Tracy R. Slatyer, Varun Vaidya   +3 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A Dark-Matter Search Using the Final CDMS II Dataset and a Novel Detector of Surface Radiocontamination [PDF]

, 2012
Substantial evidence from galaxies, galaxy clusters, and cosmological scales suggests that ~85% of the matter of our universe is invisible. The missing matter, or "dark matter" is likely composed of non-relativistic, non-baryonic particles, which have ...
Ahmed, Zeeshan
core   +1 more source

Coherence from interference: a solvable model of sub-GeV dark matter-nucleus scattering

Journal of High Energy Physics
How do dark matter-nucleus interactions transition from the regimes of coherent scattering, where single phonons are produced, to that of individual nuclear recoils? Answering this question relies on understanding multiphonon excitations.
Lynn Lin, Tongyan Lin, Momei Fang
doaj   +1 more source