Results 61 to 70 of about 92,121 (267)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effective field theory and scalar triplet dark matter

Journal of High Energy Physics
We discuss an extension of the standard model with a real scalar triplet, T, including non-renormalizable operators (NROs) up to d = 6. If T is odd under a Z 2 symmetry, the neutral component of T is a good candidate for the dark matter (DM) of the ...
Carolina Arbeláez, Marcela González, Martin Hirsch, Nicolás A. Neill, Diego Restrepo   +4 more
doaj   +1 more source

The Migdal effect in semiconductors for dark matter with masses below ∼ 100 MeV

Journal of High Energy Physics, 2023
Dark matter scattering off a nucleus has a small probability of inducing an observable ionization through the inelastic excitation of an electron, called the Migdal effect.
Kim V. Berghaus, Angelo Esposito, Rouven Essig, Mukul Sholapurkar   +3 more
doaj   +1 more source

Minimal model for dark matter and unification [PDF]

Physical Review D, 2006
Gauge coupling unification and the success of TeV-scale weakly interacting dark matter are usually taken as evidence of low energy supersymmetry (SUSY). However, if we assume that the tuning of the higgs can be explained in some unnatural way, from environmental considerations for example, SUSY is no longer a necessary component of any Beyond the ...
Mahbubani, Rakhi, Senatore, Leonardo
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

SIMPly add a dark photon

Journal of High Energy Physics, 2023
Pions of a dark sector gauge group can be strongly interacting massive particle (SIMP) dark matter, produced by the freeze-out of 3 → 2 interactions, with naturally large self-interactions. We study if adding a dark photon to the set-up can do it all: i)
Pieter Braat, Marieke Postma
doaj   +1 more source

Indirect dark matter searches and models [PDF]

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2012
Indirect dark matter searches are briefly reviewed. Current experimental data from satellites and Cherenkov telescopes searching for antimatter and gamma rays in galactic and extragalactic regions, are compared with predictions from theoretical models of dark matter.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Search for Milli-Charged particles from the Sun at IceCube

Journal of High Energy Physics, 2022
It is assumed that heavy dark matter particles ϕ with O(TeV) mass captured by the Sun may decay to relativistic light milli-charged particles (MCPs). These MCPs could be measured by the IceCube detector.
Ye Xu
doaj   +1 more source

Models for self-resonant dark matter

Journal of High Energy Physics, 2022
Abstract We consider a new mechanism for enhancing the self-scattering and annihilation cross sections for dark matter with multiple components but without a light mediator. The lighter dark matter component plays a role of the u-channel pole in the elastic co-scattering for dark matter, leading to a large self-scattering cross ...
Seong-Sik Kim, Hyun Min Lee, Bin Zhu
openaire   +3 more sources