Results 61 to 70 of about 86,395,692 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

DARKSUSY – A NUMERICAL PACKAGE FOR DARK MATTER CALCULATIONS IN THE MSSM

, 2001
The question of the nature of the dark matter in the Universe remains one of the most outstanding unsolved problems in basic science. One of the best motivated particle physics candidates is the lightest supersymmetric particle, assumed to be the ...
EDWARD A. BALTZ, LARS BERGSTRÖM, Ullio P, JOAKIM EDSJÖ, PIERO ULLIO, PAOLO GONDOLO, Bergstrom L, Baltz EA, Gondolo P, Edsjo J   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Self-interaction of super-resonant dark matter

Journal of High Energy Physics
The ΛCDM model, while successful on large cosmological scales, faces challenges on small scales. A promising solution posits that dark matter (DM) exhibits strong self-interaction, enhanced through the narrow resonance or Sommerfeld effects.
Shao-Song Tang, Murat Abdughani
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Clustering of Dark Matter, Haloes & Galaxies [PDF]

, 2008
In this thesis I study the spatial distribution of galaxies, haloes and dark matter particlesin the Universe. The subjects investigated are conceptually divided into three areas.One line of research, which is made up of Chapters 2 and 3， is to explore ...
Raúl Esteban Angulo de la Puente,
core  

Models of Supersymmetry for Dark Matter [PDF]

, 2017
A brief review of supersymmetric models and their candidates for dark matter is carried out. The neutralino is a WIMP candidate in the MSSM where R-parity is conserved, but this model has the μ problem.
Muñoz Carlos, Carlos Muñoz
core   +1 more source

Limits on spin-dependent WIMP-proton cross-sections using the DRIFT-IId directional dark matter detector [PDF]

, 2011
The nature of dark matter remains one of the biggest questions in physics today. Weakly Interacting Massive Particles (WIMPs) are a particularly well motivated candidate for the missing matter that makes up 85% of the mass of the Universe.
Pipe, Mark
core   +4 more sources

Coscattering dark matter in the inverse scotogenic model

Journal of High Energy Physics
The Scotogenic mechanism is an appealing pathway to naturally explain the common origin of dark matter and tiny neutrino mass. However, the conventional scotogenic dark matter usually suffers stringent constraints from the non-observation of lepton ...
Ang Liu, Zhi-Long Han, Fei Huang, Feng-Lan Shao, Wei Wang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source