Results 61 to 70 of about 137,955 (315)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Phenomenological models of dark energy interacting with dark matter [PDF]

, 2015
An interaction between dark matter and dark energy is usually introduced by a phenomenological modification of the matter conservation equations, while the Einstein equations are left unchanged.
Nicola Tamanini
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Troubles mounting for multipolar dark matter

Journal of High Energy Physics
In this paper, we revisit the experimental constraints on the multipolar dark matter that has derivative coupling to the visible sector mediated by the Standard Model photon.
Debajit Bose, Debtosh Chowdhury, Poulami Mondal, Tirtha Sankar Ray   +3 more
doaj   +1 more source

Secluded dark matter in gauged B − L model

Journal of High Energy Physics, 2022
We consider the gauged B − L model which is extended with a secluded dark sector, comprising of two dark sector particles. In this framework the lightest Z $$ \mathcal{Z} $$ 2-odd particle is the dark matter candidate, having a feeble interaction with ...
Priyotosh Bandyopadhyay, Manimala Mitra, Rojalin Padhan, Abhishek Roy, Michael Spannowsky   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Connection Between Galaxies and Their Dark Matter Halos [PDF]

Annual Review of Astronomy and Astrophysics, 2018
In our modern understanding of galaxy formation, every galaxy forms within a dark matter halo. The formation and growth of galaxies over time is connected to the growth of the halos in which they form.
Risa Wechsler, J. Tinker
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The hMSSM with a light gaugino/higgsino sector: implications for collider and astroparticle physics

Journal of High Energy Physics, 2023
The hMSSM is a special parameterization of the minimal supersymmetric extension of the Standard Model (MSSM) in which the mass of the lightest Higgs boson is automatically set to the LHC measured value, M h =125 GeV, by adjusting the supersymmetric ...
Giorgio Arcadi, Abdelhak Djouadi, Hong-Jian He, Jean-Loic Kneur, Rui-Qing Xiao   +4 more
doaj   +1 more source