Results 1 to 10 of about 1,986,173 (120)

Advantages and Progress of Using Chinese Hamsters to Construct Disease Models

Shiyan dongwu yu bijiao yixue, 2021
Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping, CHEN Zhaoyang, XUAN Ruijing, ZHANG Ruihu, SONG Guohua   +4 more
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The role of m6A modification in the biological functions and diseases

Signal Transduction and Targeted Therapy, 2021
N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen   +7 more
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Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells

Viruses, 2022
Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process.
Ying Lu, Ming-Xu Zhang, Wei Pang, Tian-Zhang Song, Hong-Yi Zheng, Ren-Rong Tian, Yong-Tang Zheng   +6 more
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Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants

BMC Medicine, 2022
Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD ...
Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo   +8 more
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Similarities and differences in placental development between humans and cynomolgus monkeys

Reproductive Medicine and Biology, 2023
Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto, Eiichi Okamura, Masanaga Muto, Masatsugu Ema   +3 more
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Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

Genome Medicine, 2022
Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.
Rui Chen, Zhihui Yang, Jiewei Liu, Xin Cai, Yongxia Huo, Zhijun Zhang, Ming Li, Hong Chang, Xiong-Jian Luo   +8 more
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Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China

BMC Infectious Diseases, 2021
Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern.
Yu Wang, Xin Chen, Mei Ye, Wei Pang, Chiyu Zhang, Si-Dong Xiong, Yong-Tang Zheng   +6 more
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WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome

Biology, 2022
(1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1.
Hongyan Li, Fang Liu, Hanzhe Kuang, Hua Teng, Siyi Chen, Sijing Zeng, Qimin Zhou, Zhaokai Li, Desheng Liang, Zhuo Li, Lingqian Wu   +10 more
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Gain and loss events in the evolution of the apolipoprotein family in vertebrata

BMC Evolutionary Biology, 2019
Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers.
Jia-Qian Liu, Wen-Xing Li, Jun-Juan Zheng, Qing-Nan Tian, Jing-Fei Huang, Shao-Xing Dai   +5 more
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Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

Virology Journal, 2020
Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu, Chuan Qin   +6 more
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