Results 11 to 20 of about 1,986,272 (219)
Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes
Virology Journal, 2021 Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus.
Xin Li +10 more
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Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
Nature Communications, 2019 Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting ...
Tomoyuki Tsukiyama +20 more
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BMC Medicine, 2023 Background Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms.
Zhi-Hui Yang +13 more
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Scientific Reports, 2017 The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging.
Hong-Yi Zheng +11 more
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Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications
Toxins, 2015 Venomous animals have evolved with sophisticated bio-chemical strategies to arrest prey and defend themselves from natural predators. In recent years, peptide toxins from venomous animals have drawn considerable attention from researchers due to their ...
Md Abdul Hakim, Shilong Yang, Ren Lai
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Bidirectional genetic overlap between bipolar disorder and intelligence
BMC Medicine, 2022 Background Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. Methods To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from ...
Meng-Yuan Shang +8 more
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Molecular Cancer, 2021 Background Non-small cell lung cancer (NSCLC) is the most common type of human lung cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play important roles in NSCLC, limiting ...
Yaomei He +10 more
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ResearchThe ANK2 gene mutations are marked risk factors for autism spectrum disorder, one of the neurodevelopmental disorders (NDDs) that often extends into adulthood and has a complex etiology involving genetic and environmental factors.
Hong-Di Huang +23 more
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Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Nature Communications, 2019 We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory ...
Yongxia Huo +4 more
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Cell Reports, 2016 Here, we examine whether neurons differentiated from transplanted stem cells can integrate into the host neural network and function in awake animals, a goal of transplanted stem cell therapy in the brain.
Jing-kuan Wei +23 more
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