Results 41 to 50 of about 7,576,134 (299)

The Russo-Turkish war (the campaign of 1789) in the light of reports from „Pamiętnik Historyczno-Polityczno-Ekonomiczny”

open access: yesPrzegląd Nauk Historycznych, 2017
The subject of the article is the Russo-Turkish war of 1787–1792, more precisely the campaign of 1789. The issue will be discussed basing on the information published in „Pamiętnik Historyczno-Polityczno-Ekonomiczny”. The journal was coming out in Warsaw
Małgorzata Karkocha
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The French Socialist and German Social Democratic Parties and the Future of the Working Class in the European Coal & Steel Community, 1948-1954

open access: yesDiacronie. Studi di Storia Contemporanea, 2012
Although the status of workers in the European Coal & Steel Community (ECSC) was not the determining factor in French Socialist (SFIO) and German Social Democratic (SPD) policy towards the Schuman Plan, the two parties made sustained efforts to protect ...
Brian Shaev is a doctoral candidate in Modern European History at the University of Pittsburgh.
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Modern diagnosis of GERD: the Lyon Consensus

open access: yesGut, 2018
Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal
C. Gyawali   +16 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Study of Nation and Patria as Communities of Identity: Theory, Historiography, and Methodology from the Spanish Case

open access: yesGenealogy, 2020
This article argues for a renovation in the study of nationalism by addressing the issue of the rationality underlying the decisions by citizens willing to leave their homelands.
Pablo Sánchez León
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Between planning euphoria and civil resistance: the construction of the “Hüttentalentlastungsstraße” in Siegen (approx. 1960–2000) [PDF]

open access: yesGeographica Helvetica
This article focuses on the experience of loss in urban spaces in late modernity, taking as a graphic example the construction of an urban highway and its consequences in a densely populated and geographically challenging area in western Germany.
D. Mysliwietz-Fleiß
doaj   +1 more source

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