Results 21 to 30 of about 74,543,651 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scientific journal “Library Science. Record Studies. Informology”, 2019 Purpose of the article. The research is connected with the analysis of librarianship publications on the issues of preservation of documents in libraries of Ukraine. Methodology. In the process of research, scientific methods of analysis, synthesis, generalization and historiographical method have been applied.
Sydorenko, Tаtyana, Fihura, Alona
openaire +3 more sources
International Journal of Digital Content Management, 2021 Libraries have long been involved in content management due to their mission and task, but with the advent of the digital age, this content has changed from print to digital. Digital content management is related to storing, organizing, indexing and monitoring digital content used by an organization.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Post-nonclassical Practices in Modern Library Researches
Bibliotekovedenie [Russian Journal of Library Science], 2011 On the prospect of postnonclassical practices’ using in library researches. Methodology of postnonclassical science opens a new stage in the development of library and information science: postnonclassical practices form new approaches to the library studies and librarianship amid innovation and transformation towards the information society and ...
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
British Library Research Report 2017-18
, 2019 The Library’s role as an Independent Research Organisation (IRO) is central to our research identity, supporting a thriving research culture and enabling us to lead and partner on high level research.
British Library
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
British Library open access policy for staff research outputs
, 2019 The Living Knowledge vision of the British Library is to make our intellectual heritage accessible to everyone, for research, inspiration and enjoyment.
British Library
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