Results 31 to 40 of about 74,543,651 (311)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Strategi pengembangan desain interior terhadap kenyamanan pemustaka di Perpustakaan Umum Daerah Kabupaten Lima Puluh Kota

Daluang
Purpose. This study examines development strategies to improve the comfort of use in the Regional Public Library of Lima Puluh Kota Regency. Library interior design is important in creating an environment that supports learning, and research, and ...
Cut Afrina, Sri Rohyanti Zulaikha, Atika Fatma Delvi, Ayu Shafutri, Bunga Fedra Refandi, Hafizhand Lutfilhadi, M. Iqbal Zulfa, Safrinal S.   +7 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Library-information activity as an object of senior pupils professional self-determination

Библиосфера, 2017
A modern specialist of library-information work should quickly solve extraordinary information problem, professionally carry out expert-consulting, research, design and creative activity.
V. V. Mishova, E. N. Ogneva
doaj   +1 more source

Research and Methodical Development in the Library Sphere: Modern Trends

Bibliotekovedenie [Library and Information Science (Russia)], 2016
The article examines the current stage of scientific and methodical development in the field of librarianship. There are identified the new trends in the directions, forms, organizational structure of the methodical work. There is analyzed the methodical practice of federal and regional methodical centres.
openaire   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Theoretical and Methodological Comprehension of Library Design

Библиосфера
The article reveals theoretical and methodological approaches to innovative and project activiries of modern libraries. Relevance of research is conditioned by the necessity of comprehension of the problem field of library project planning in modern ...
N. L. Golubeva
doaj   +1 more source

The Philological Library as a Modern Architectural Icon for Knowledge and Research

Indian Journal of Information Sources and Services
This article explores the evolving role of philological libraries as modern architectural icons that not only preserve linguistic and literary heritage but also actively shape the dynamics of knowledge production and academic research. Taking the Philological Library at Freie Universität Berlin as a focal point, the study investigates the intersection ...
Abdurahim Mannonov, Ra'no Davlatova, Fazilat Ibragimova, Shirin Rakhmonova, Shakhnoza Yuldoshova, Feruza Makhamatova, Sarvar Atajanov, Barno Sharipova   +7 more
openaire   +1 more source