Results 81 to 90 of about 58,406 (215)

Translational pharmacokinetic/pharmacodynamic model for mRNA‐0184, an investigational therapeutic for the treatment of heart failure

Clinical and Translational Science
Heart failure (HF) is a complex, progressive disorder that is associated with substantial morbidity and mortality on a global scale. Relaxin‐2 is a naturally occurring hormone that may have potential therapeutic benefit for patients with HF.
Neeraj Kaushal, Husain Attarwala, Mir Javid Iqbal, Rajnish Saini, Linh Van, Min Liang   +5 more
doaj   +1 more source

Development and validation of the Essen Melanoma Quality of Life Inventory (EMQoLI)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives New treatments for melanoma, such as targeted therapy and immunotherapy, present unique adverse events compared to traditional treatments like surgery and chemotherapy. Existing health‐related quality of life (HRQoL) measures often fail to address these new treatment effects and focus primarily on chemotherapy and ...
Venja Musche, Theresa Schadendorf, Adam Schweda, Georg Lodde, Jessica Neumann, Lisa Zimmer, Svea Hüning, Dirk Schadendorf, Eva‐Maria Skoda, Elisabeth Livingstone, Martin Teufel   +10 more
wiley   +1 more source

Immunostimulatory/Immunodynamic model of mRNA‐1273 to guide pediatric vaccine dose selection

CPT: Pharmacometrics & Systems Pharmacology
COVID‐19 vaccines, including mRNA‐1273, have been rapidly developed and deployed. Establishing the optimal dose is crucial for developing a safe and effective vaccine. Modeling and simulation have the potential to play a key role in guiding the selection
Vijay Ivaturi, Husain Attarwala, Weiping Deng, Baoyu Ding, Sabine Schnyder Ghamloush, Bethany Girard, Javid Iqbal, Saugandhika Minnikanti, Honghong Zhou, Jacqueline Miller, Rituparna Das   +10 more
doaj   +1 more source

Shifts in Incident Glucose Lowering Drug Initiation in Type 2 Diabetes From 2014 to 2024: A Population‐Based Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to analyse incident glucose lowering drug (GLD) utilisation in Australia between the period 2014 and 2024. Materials and Methods Australian Pharmaceutical Benefits Scheme (PBS) data (10% PBS dataset) were analysed to assess the proportions of incident monotherapy, dual therapy and triple therapy and the proportion of ...
Peter S. Hamblin, Stella Talic, Harvey J. W. Koh, Arul Earnest, Anthony W. Russell, Sophia Zoungas   +5 more
wiley   +1 more source

Columnata Moderna

Arquitecturas del Sur, 1986
La arquitectura del movimiento moderno preconizó un replanteamiento estilístico total del edificio acompañado de una simplificación geométrica del volumen, y reconoció la necesidad de considerar en el diseño de la obra el avance tecnológico contemporáneo.
Eduardo Meissner Grebe, Hans Fox Timmling   +1 more
openaire   +1 more source

HIV‐1 viral load and reservoir size remain stable following SARS‐CoV‐2 mRNA vaccination in people with HIV

HIV Medicine, EarlyView.
Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri, Bianca B Jütte, Jan Vesterbacka, Soo Aleman, Hans‐Gustaf Ljunggren, Marcus Buggert, J Peter Svensson, Anders Sönnerborg, Piotr Nowak   +8 more
wiley   +1 more source

Dynamics of High‐Growth Young Firms and the Role of Venture Capitalists

International Economic Review, EarlyView.
ABSTRACT Motivated by the substantial growth and upfront investments of venture capital (VC)‐backed firms observed in administrative US Census data, this study develops a life‐cycle firm dynamics model. In the model, startups choose the source of financing from VC, angel investors, or banks, depending on their growth potential, and invest in innovation.
Yoshiki Ando
wiley   +1 more source

Tudor England and Stewart Scotland Through Spanish Eyes: A Complete Transcription and Translation of Pedro de Ayala's Letter of 1498 to King Ferdinand of Castile and Queen Isabella of Aragon

Renaissance Studies, EarlyView.
Abstract Pedro de Ayala served as a diplomat for King Ferdinand II of Aragon and Queen Isabella I of Castile at the courts of Henry VII, King of England, and James IV, King of Scots. In July 1498, he wrote a letter, partly in cipher, to report to his king and queen on such matters as Spain's interests in international diplomacy; the characters and ...
Adrian William Jaime, Valeria Tapia Cruz, Mairi Cowan   +2 more
wiley   +1 more source

Reading Dürer in Late Sixteenth‐Century Padua: Matteo Macigni (ca. 1510–1582), His Library and the Annotated Institutionum geometricarum (Paris, 1535)

Renaissance Studies, EarlyView.
ABSTRACT This article contributes to the history of material culture and intellectual biography by definitively identifying the Paduan scholar Matteo Macigni (ca. 1510–1582) as the author of the annotations found in a 1535 copy of Albrecht Dürer’s Institutionum geometricarum currently preserved in Vicenza.
Laura Moretti
wiley   +1 more source

More Science Than Art: The First Botanical Garden in Portugal (c. 1650)

Renaissance Studies, EarlyView.
ABSTRACT Gabriel Grisley, a German physician, came to Portugal and founded a garden near the Xabregas River in Lisbon, during the 1610s under the Spanish kings' rule. In view of the utility a botanic garden represented for the kingdom, he was able to obtain a royal privilege from King João IV during the Restauration War against the Spanish (1640–1668).
Ana Duarte Rodrigues
wiley   +1 more source