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Geografias Moderna e Pós-Modernas

GEOgraphia, 2009
Resumo Instituído e sucessivamente recriado no âmbito da modernidade, o discurso geográfico vê-se já de um tempo desafiado pelas críticas e referências do pós-moderno. Sobretudo em face de as mudanças recentes envolvendo a geografia humanista e a geografia crítica terem passado ao largo do avanço ...
openaire   +2 more sources

Comparative Effectiveness and Antibody Responses to Moderna and Pfizer-BioNTech COVID-19 Vaccines among Hospitalized Veterans — Five Veterans Affairs Medical Centers, United States, February 1–September 30, 2021

MMWR. Morbidity and mortality weekly report, 2021
The mRNA COVID-19 vaccines (Moderna and Pfizer-BioNTech) provide strong protection against severe COVID-19, including hospitalization, for at least several months after receipt of the second dose (1,2).
Kristina L. Bajema, R. Dahl, Steve L. Evener, M. Prill, M. Rodriguez‐Barradas, V. Marconi, D. Beenhouwer, M. Holodniy, C. Lucero-Obusan, Sheldon T. Brown, Maraia R. Tremarelli, Monica Epperson, Lisa Mills, S. Park, Gilberto Rivera-Dominguez, Rosalba Gomez Morones, Ghazal Ahmadi-Izadi, Rijalda Deović, Chad Mendoza, Chan Jeong, S. Schrag, E. Meites, A. Hall, Miwako Kobayashi, M. McMorrow, J. Verani, N. Thornburg, D. Surie, J. Burnette, Gustavo Capo, L. Epstein, Julia W. Gallini, Telisha Harrison, A. Hartley, L. Hernández, Elena Morales, N. Patel, Kim Rooney, Tehquin Tanner, E. Tate, Ashley Tunson, Alexis Whitmire, Juton R. Winston, K. Elliot, Ilda Graham, Diki Lama, Ismael Pena, A. Perea, Guerry Anabelle Perez, Johane Simelane, Sarah Smith, G. Tallin, A. Tisi, A. Lopez, Miguel Covarrubias Gonzalez, Bashir Lengi, Mariana Vanoye Tamez, B. Aryanfar, Ian Lee-Chang, Anthony Z. Matolek, A. Poteshkina, Saadia Naeem, Evan Goldin, Madhuri Agrawal, J. López, Theresa Peters, G. Kudryavtseva, J. Cates, Anita K Kambhampati   +68 more
semanticscholar   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria

Nature Communications
Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic acidemia (MMA), and phenylketonuria (PKU).
Rena Baek, Kimberly Coughlan, Lei Jiang, Min Liang, Lei Ci, Harkewal Singh, Hannah Zhang, Neeraj Kaushal, Ivana Liric Rajlic, Linh Van, Rain Dimen, Alexander Cavedon, Ling Yin, Lisa Rice, Andrea Frassetto, Lin Guey, Patrick Finn, Paolo G. V. Martini   +17 more
doaj   +1 more source

Comparison of IgA, IgG, and Neutralizing Antibody Responses Following Immunization With Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm’s COVID-19 Vaccines

Frontiers in Immunology, 2021
In an ongoing multinational trial, we obtained blood samples from 365 volunteers vaccinated with mRNA vaccines (Moderna, BioNTech), viral DNA-vectored vaccines (AstraZeneca, Sputnik-V, and Johnson and Johnson), or the attenuated virus vaccine from ...
T. Adjobimey, J. Meyer, Leander Sollberg, Michael Bawolt, C. Berens, P. Kovačević, A. Trudić, M. Parčina, A. Hoerauf   +8 more
semanticscholar   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Stevens–Johnson syndrome precipitated by Moderna Inc. COVID‐19 vaccine: a case‐based review of literature comparing vaccine and drug‐induced Stevens–Johnson syndrome/toxic epidermal necrolysis

International Journal of Dermatology, 2022
The Moderna COVID‐19 vaccination was approved for use in the United States in December of 20201 and since that time massive public health efforts have been made to vaccinate patients against the COVID‐19 infection.
J. Padniewski, E. Jacobson-Dunlop, S. Albadri, S. Hylwa   +3 more
semanticscholar   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Immunogenicity and safety of mRNA-based seasonal influenza vaccines encoding hemagglutinin and neuraminidase

Nature Communications
Current influenza vaccines induce immune responses to hemagglutinin (HA), a surface glycoprotein of seasonal influenza viruses, but have suboptimal effectiveness. mRNA vaccines may improve protection by targeting additional antigens such as neuraminidase
Amanda K. Rudman Spergel, Ivan T. Lee, Kindra Koslovsky, Kristi Schaefers, Andrei Avanesov, Douglas K. Logan, John Hemmersmeier, David Ensz, Daniel Stadlbauer, Bo Hu, Alicia Pucci, Jignesh Vakil, Robert Paris, Jintanat Ananworanich, Raffael Nachbagauer   +14 more
doaj   +1 more source

Bullous Pemphigoid Following the Moderna mRNA-1273 Vaccine

Cureus, 2022
As the onset of novel variants of the severe acute respiratory syndrome coronavirus 2 virus pushes policy-makers to push widespread vaccination efforts, it is likely that an increased number of severe cutaneous adverse reactions (SCARs) will present ...
Amar D. Desai, Radhika A Shah, A. Haroon, C. Wassef   +3 more
semanticscholar   +1 more source