Results 41 to 50 of about 394,456 (275)

Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States

Infectious Diseases and Therapy
Introduction In September 2023 the Food and Drug Administration (FDA) approved an updated mRNA COVID-19 vaccine targeting the XBB.1.5 sublineage. This study evaluates the effectiveness of mRNA-1273.815, a 2023–2024 Omicron XBB.1.5-containing mRNA COVID ...
Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A. Marks, Katherine E. Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B. Araujo   +18 more
doaj   +1 more source

Risk factors for severe COVID-19 outcomes in the Asia-Pacific region: a literature review

Frontiers in Public Health
This comprehensive synthesis of severe COVID-19 risk factors specific to the Asia-Pacific (APAC) region addresses gaps in previous global studies, which often overlook regional demographic, epidemiological, and healthcare system variations.
Madeline Thompson, Amanda K. Buttery, Shu Xin Oh, Macy Chan, Byung Hyun Lee, Tomoharu Iino, Yu-Chun Alice Wang, Chris Clarke   +7 more
doaj   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Immune correlates analysis in NextCOVE trial for a next-generation mRNA-1283 COVID-19 vaccine

Human Vaccines & Immunotherapeutics
SARS-CoV-2 neutralizing antibodies (nAbs) are strongly inversely associated with COVID-19 risk and have correlated with vaccine efficacy across multiple clinical trials conducted during the COVID-19 pandemic.
Chong Ma, Jing Feng, Rahnuma Wahid, Spyros Chalkias, Darin Edwards, Bethany Girard, Rituparna Das, Honghong Zhou, Lingyi Zheng   +8 more
doaj   +1 more source

Real-World Effectiveness of a Third Dose of mRNA-1273 Versus BNT162b2 on Inpatient and Medically Attended COVID-19 Among Immunocompromised US Adults

Infectious Diseases and Therapy
Introduction Recent data have shown elevated infection rates in several subpopulations at risk of SARS-CoV-2 infection and COVID-19, including immunocompromised (IC) individuals.
Tianyu Sun, Linwei Li, Katherine E. Mues, Mihaela V. Georgieva, Brenna Kirk, James A. Mansi, Nicolas Van de Velde, Ekkehard C. Beck   +7 more
doaj   +1 more source

Effectiveness of 2023–2024 mRNA-1273 XBB.1.5 vaccine against COVID-19 associated hospitalizations and medically attended COVID-19 in the United States

Vaccine: X
Background: COVID-19 remains a public health concern, causing an estimated 50,000 deaths and 827,000 hospitalizations in the United States during the 2023–2024 season.
Zhe Zheng, Mitra Yousefi, Danielle MacCormac, Jennifer M. Radin, Tianyu Sun, Amanda Wilson, Rohan Shah, Michelle Skornicki, Paige Sheridan, Astra Toyip, Katherine Mues, Daina Esposito, Andre Araujo, Evan Anderson   +13 more
doaj   +1 more source

Generation of a mouse model of Primary Hyperoxaluria Type 1 via CRISPR/Cas9 mediated gene editing

Journal of Biochemical and Clinical Genetics, 2019
Background: Primary Hyperoxaluria Type 1 (PH1) is an inborn error of metabolism caused by mutations in the AGXT gene, which encodes for the hepatocyte-specific enzyme alanine: glyoxylate aminotransferase (AGT).
Kimberly A Coughlan, Rajanikanth J Maganti, Andrea Frassetto, Christine M DeAntonis, meredith Wolfrom, Anne-Renee Graham, Shawn M Hillier, Steven Fortucci, Hoor Al Jandal, Sue-Jean Hong, Paloma H Giangrande, Paolo GV Martini   +11 more
doaj   +1 more source

Prenatal SARS‐CoV‐2 infection, COVID‐19 vaccination, and preschool neurodevelopment: A confounder‐adjusted cohort study

JCPP Advances, EarlyView.
Abstract Background The impact of maternal SARS‐CoV‐2 infection and COVID‐19 vaccination during pregnancy on child neurodevelopment remains unclear, with most studies limited by small samples and short follow‐up periods. This prospective cohort study assesses internalizing, externalizing, total problem behaviors, and social responsiveness in children ...
Marco Rizzo, Rushna Tubassum, Floriana Milazzo, Yasemin Schmitt, Whitney Lieb, Maria De Las Mercedes Perez‐Rodriguez, Lot D. de Witte, Veerle Bergink, Anna‐Sophie Rommel   +8 more
wiley   +1 more source

Discovery of Novel Ionizable Lipids for Lipid Nanoparticles: Lipophilicity as a Predictor of Squaramide Head Group Lipid Clearance

Small Science
Ionizable lipids are a critical component of lipid nanoparticles (LNPs) for messenger RNA (mRNA) delivery, driving cellular uptake, endosomal escape, and tolerability.
E. Sathyajith Kumarasinghe, Edward J. Hennessy, Michael W. Danneman, Kristine E. Burke, Timothy Salerno, Erin E. Giardino, Matthew D. Crawford, Erin L. Thomas, Paulo L. Markaj, Farbod Mahmoudinobar, Edward Acosta, Carla Leite, Kerry E. Benenato, Juneyoung Lee, Mohindra Seepersaud   +14 more
doaj   +1 more source

Subcorneal Pustular Dermatosis, a Systematic Review and Pooled Analysis of a Rare and Underdiagnosed Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, relapsing pustular skin condition of unknown cause, characterised by subcorneal pustules. Objectives To summarise the demographic, clinical, histopathological, management and disease course of SPD.
Mason H. Crossman, Jeffrey Weng, Alysha Vuong, Lawrence Lin, Zhao Feng Liu, Christopher Y. Chew   +5 more
wiley   +1 more source