Results 21 to 30 of about 394,456 (275)

Geografias Moderna e Pós-Modernas

GEOgraphia, 2009
Resumo Instituído e sucessivamente recriado no âmbito da modernidade, o discurso geográfico vê-se já de um tempo desafiado pelas críticas e referências do pós-moderno. Sobretudo em face de as mudanças recentes envolvendo a geografia humanista e a geografia crítica terem passado ao largo do avanço ...
openaire   +2 more sources

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria

Nature Communications
Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic acidemia (MMA), and phenylketonuria (PKU).
Rena Baek, Kimberly Coughlan, Lei Jiang, Min Liang, Lei Ci, Harkewal Singh, Hannah Zhang, Neeraj Kaushal, Ivana Liric Rajlic, Linh Van, Rain Dimen, Alexander Cavedon, Ling Yin, Lisa Rice, Andrea Frassetto, Lin Guey, Patrick Finn, Paolo G. V. Martini   +17 more
doaj   +1 more source

Odontología Moderna

Revista Odontológica Mexicana Órgano Oficial de la Facultad de Odontología UNAM, 2022
La odontología en la actualidad ha sufrido severas modificaciones conforme las exigencias de la vida moderna, las diferentes enfermedades de esta era tales como cáncer, SIDA y el virus del papiloma humano, obligan a nuestros especialistas a prepararse mejor para poder atender de manera profesional a estos grupos de pacientes, que ya en la actualidad ...
openaire   +1 more source

Mapping the Social Network Structure and Composition of Black Individuals With Rheumatic and Musculoskeletal Conditions

Arthritis Care &Research, EarlyView.
Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi, Amar Dhand, Leah Santacroce, Neil Pillai, Komel Safdar, Mia T. Chandler, Ariel Childs, Monica Crespo‐Bosque, Gina Curry, Mary Dollear, Alice Eggleston, Daniel Erickson, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Tyler Green, Magdalena Hamielec, Elena Losina, Karen Mancera‐Cuevas, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Tonya S. Roberson, Mary Beth Son, Marie Jacques Toussaint, Michael York, Rosalind Ramsey‐Goldman, Candace H. Feldman   +27 more
wiley   +1 more source

mRNA-1010 influenza vaccine elicits distinct and enhanced humoral immunity compared to adjuvanted inactivated vaccines

npj Vaccines
Causing approximately a billion infections globally annually, the influenza virus represents one of the globe’s greatest viral threats. While current vaccines protect against severe outcomes, especially for vulnerable populations, they offer limited ...
Paulina Kaplonek, Roger Vargas, Jessica Shih-Lu Lee, Harry Bertera, Eleanor Astley, Bethany Girard, Jaap Oostendorp, Carole Henry, Robert Paris, Wen-Han Yu, Galit Alter   +10 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 Vaccination with mRNA-1273

Infectious Diseases and Therapy
Introduction Detailed characterization of the antibody profile induced by SARS-CoV-2 mRNA vaccines has shown that repeat dosing boosts all immunoglobulin G (IgG) subclasses, with a notable emergence of antigen-specific IgG4 antibodies.
Paulina Kaplonek, Harry Bertera, Diana W. Lee, Deniz Cizmeci, Wen-Han Yu, Kai Wu, Spyros Chalkias, Rahnuma Wahid, Darin Edwards, Galit Alter, Carole Henry   +10 more
doaj   +1 more source

refloraR: An R package for efficiently retrieving and analyzing plant specimen data from the Herbário Virtual Reflora

Applications in Plant Sciences, EarlyView.
Abstract Premise Advances in the digitization of herbarium collections are enabling open access to specimen data for research and conservation. In Brazil, the Herbário Virtual Reflora (HVR) hosts over 4.8 million high‐resolution images of botanical specimens and their associated data from 86 national and international herbaria.
Carlos Calderón del Cid, Ana Flávia Alves Versiane, Paula Leitman, Fabiana Ranzato Filardi, Rafaela Campostrini Forzza, Domingos Cardoso   +5 more
wiley   +1 more source