Results 11 to 20 of about 58,406 (215)

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

UMA GRAMÁTICA MODERNA

Revista Projetar - Projeto e Percepção do Ambiente, 2021
Em teorias normativas ou prescritivas, os requisitos arquitetônicos são definidos como parâmetros para apoiar as decisões de projeto. Um conjunto de parâmetros formais é suficiente para gerar uma grande variedade de composições, quase sempre associadas a uma mesma linguagem formal.
Luiz Manuel do Eirado Amorim, Cristiana Griz, Yara Bezerra   +2 more
openaire   +3 more sources

Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

Nature Communications, 2020
Propionic acidemia is a serious pediatric inherited disorder with no effective treatments. Here the authors demonstrate that delivering dual mRNAs as an enzyme replacement approach can be used as an effective therapy in a mouse model of propionic ...
Lei Jiang, Ji-Sun Park, Ling Yin, Rodrigo Laureano, Eric Jacquinet, Jinsong Yang, Shi Liang, Andrea Frassetto, Jenny Zhuo, Xinhua Yan, Xuling Zhu, Steven Fortucci, Kara Hoar, Cosmin Mihai, Christopher Tunkey, Vlad Presnyak, Kerry E. Benenato, Christine M. Lukacs, Paolo G. V. Martini, Lin T. Guey   +19 more
doaj   +1 more source

Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape

Human Vaccines & Immunotherapeutics, 2023
Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Rituparna Das, Randall N. Hyer, Paul Burton, Jacqueline M. Miller, Barbara J. Kuter   +4 more
doaj   +1 more source

Século XXI: educação moderna ou pós-moderna?

Revista Iberoamericana de Educación, 2013
La sociedad tiene pasado por conflictos en el plan axiológico, ético, de identidad, entre la verdad y el mito, confirmación y negación de la historia que repercute directamente en la producción académica y en los rumbos que las ciencias deben seguir.
Montysuma, Hilda, Bonito, Jorge
openaire   +5 more sources

An mRNA influenza vaccine induces immunity comparable to an adjuvanted vaccine in a randomized trial

npj Vaccines
Influenza causes substantial morbidity and mortality worldwide. This randomized, open-label, phase 1 trial (ClinicalTrials.gov, NCT05397223, date of registration: May 31, 2022) compared the immunogenicity of an mRNA-based quadrivalent influenza ...
Carole Henry, Daniel Makrinos, Runxia Liu, Maria Cavallaro, Brooke Fenderson, Yanbo Sun, Xiaolin Chang, Eleanor Astley, Bethany Girard, Wen-Han Yu, Jaap Oostendorp, Anthony DiPiazza, Robert Paris   +12 more
doaj   +1 more source

A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson

Human Vaccines & Immunotherapeutics, 2022
The novel coronavirus outbreak was declared a pandemic in March 2020. We are reviewing the COVID-19 vaccines authorized for use in the United States by discussing the mechanisms of action, administration, side effects, and efficacy of vaccines developed ...
Rikin Patel, Mohamad Kaki, Venkat S. Potluri, Payal Kahar, Deepesh Khanna   +4 more
doaj   +1 more source

Geografias Moderna e Pós-Modernas

GEOgraphia, 2009
Resumo Instituído e sucessivamente recriado no âmbito da modernidade, o discurso geográfico vê-se já de um tempo desafiado pelas críticas e referências do pós-moderno. Sobretudo em face de as mudanças recentes envolvendo a geografia humanista e a geografia crítica terem passado ao largo do avanço ...
openaire   +2 more sources

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

mRNA-1010 influenza vaccine elicits distinct and enhanced humoral immunity compared to adjuvanted inactivated vaccines

npj Vaccines
Causing approximately a billion infections globally annually, the influenza virus represents one of the globe’s greatest viral threats. While current vaccines protect against severe outcomes, especially for vulnerable populations, they offer limited ...
Paulina Kaplonek, Roger Vargas, Jessica Shih-Lu Lee, Harry Bertera, Eleanor Astley, Bethany Girard, Jaap Oostendorp, Carole Henry, Robert Paris, Wen-Han Yu, Galit Alter   +10 more
doaj   +1 more source