Results 41 to 50 of about 102,174 (310)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of Biopreservatives Combined with Modified Atmosphere Packaging on the Quality of Apples and Tomatoes

Polish Journal of Food and Nutrition Sciences, 2019
During the cultivation and harvesting of fruit and vegetables, a large number of microorganisms accumulate on their surface. Their active and excessive reproduction leads to spoilage of products.
Olga Babich, Lyubov Dyshlyuk, Stanislav Sukhikh, Alexander Prosekov, Svetlana Ivanova, Valery Pavsky, Tatiana Chaplygina, Olga Kriger   +7 more
doaj   +1 more source

Modified atmosphere packaging and dark/light refrigerated storage in green leafy vegetables have impact on nutritional value [PDF]

, 2019
The consumption of zeaxanthin (Z) through a vegetable-rich diet is recommended to reduce the progression of age-related macular degeneration. Due to Z’s intrinsic dynamic character that results from its participation in the photoprotective xanthophyll ...
Becerril Soto, José María, Buezo, Javier, Esteban Terradillos, Raquel, García Plazaola, José Ignacio   +3 more
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Development of Modified Gas Composition for Atmosphere Packaging of Sliced Apple Chips

Applied Sciences
In this study, we report the development of mixed gas composition for packaging dried apple slices in a modified atmosphere to extend their shelf life and maintain their quality.
Jarosław Wyrwisz, Małgorzata Moczkowska-Wyrwisz, Marcin A. Kurek   +2 more
doaj   +1 more source

Influence of Modified Atmosphere Packaging and Frozen-Storage Period in the Colour Characteristics of Poultry Meat

Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2019
This study was carried out to investigate the effect of modified atmosphere packaging and frozen storage period in the colour characteristics of chick thigh meat.
Jalilah H. Khalaf, Majid H. Al-Asadi, Asaad R. Al-Hilphy   +2 more
doaj   +1 more source

Effects of different packaging methods on microbial, [chemical] and sensory properties of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) fillets during refrigerator storage [PDF]

, 2013
The effect of three different packaging methods including Modified Atmosphere Packaging (MAP), Vacuum Packaging and normal Packaging was investigated on the quality of Nile tilapia fresh fillets stored in the refrigerator's temperature.
Ashraf Gohari, A., Gorban Zarea, G., Jafar, M., Mashayekhi, F., Morady, Y., Rezvani Gil Kalaee, A.   +5 more
core  

Storage stability of whole and nibbed, conventional and high oleic peanuts (Arachis hypogeae L.) [PDF]

, 2013
Peanuts are increasingly being used as nibbed ingredients in cereal bars, confectionery and breakfast cereals. However, studies on their oxidative stability in this format are limited.
Ashton, Ian P., Fielding, Louise M., Tatham, Arthur S., Wilkin, Jonathan D.   +3 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source