Results 61 to 70 of about 9,581,482 (296)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Magnetohydrodynamics and viscosity variation in couple stress squeeze film lubrication between rough flat and curved circular plates

Scientific Reports, 2023
A simplified mathematical model has been developed for understanding combined effects of surface roughness, viscosity variation and couple stresses on the squeeze film behaviour of a flat and a curved circular plate in the presence of transverse magnetic
Haewon Byeon, Y. L. Latha, B. N. Hanumagowda, Vediyappan Govindan, A. Salma, Sherzod Abdullaev, Jagadish. V. Tawade, Fuad A. Awwad, Emad A. A. Ismail   +8 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Analyses of natural frequency and electromechanical behavior of flexoelectric cylindrical nanoshells under modified couple stress theory

, 2018
Different from piezoelectric effect, the flexoelectric effect is size dependent and becomes more significant at nanoscale. A nonlinear dynamic model of nanoscale flexoelectric shells is developed based on modified couples stress theory.
Wang, Baolin (R17839), Zeng, Shan, Wang, Kaifa   +2 more
core   +1 more source

Uniqueness for plane crack problems in dipolar gradient elasticity and in couple-stress elasticity [PDF]

, 2005
The present work deals with the uniqueness theorem for plane crack problems in solids characterized by dipolar gradient elasticity. The theory of gradient elasticity derives from considerations of microstructure in elastic continua [Mindlin, R.D., 1964 ...
Georgiadis, H.G., C.G. Grentzelou, Grentzelou, C.G., Georgiadis, HG, H.G. Georgiadis, Grentzelou, CG   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Buckling In Nanoplates [PDF]

Nanoscale and Advanced Materials
This study simultaneously analyzes the buckling behavior of four graphene nanoplate models—Kirchhoff, Mindlin, third-order shear deformation, and nth-order shear deformation—using the modified couple stress theory (MCST) and Navier’s analytical method ...
Majid Eskandari Shahraki, Alireza Asadolahei, Payam Mohammadi, Seyedshahab Seyedalikhani, Jafar Eskandari Jam   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source