Results 71 to 80 of about 9,581,482 (296)

Couple stress theory for solids [PDF]

, 2011
By relying on the definition of admissible boundary conditions, the principle of virtual work and some kinematical considerations, we establish the skew-symmetric character of the couple-stress tensor in size-dependent continuum representations of matter.
Ali R. Hadjesfandiari, Gary F. Dargush, Dargush, Gary F., Hadjesfandiari, Ali R.   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bifurcation analysis and nonlinear elastic behavior of FG foam-filled double cylindrical microtubes via the modified couple stress theory in thermal environment

Alexandria Engineering Journal
This paper presents a comprehensive investigation into the nonlinear wave propagation, vibration characteristics, and thermal postbuckling behavior of double cylindrical microtubes filled with functionally graded (FG) metal foam.
Sarah M. Albalawi, Mohammed Sobhy, Adel A. Elmandouh   +2 more
doaj   +1 more source

A new microstructure-dependent Saint–Venant torsion model based on a modified couple stress theory [PDF]

European Journal of Mechanics - A/Solids, 2011
In this paper a new modified couple stress model is developed for the Saint-Venant torsion problem of micro-bars of arbitrary cross section. The proposed model is derived from a modified couple stress theory and has only one material length scale parameter.
Tsiatas, G. C., Katsikadelis, J. T.
openaire   +2 more sources

Size-Dependent Torsional Buckling of Carbon Nano-Peapods Based on the Modified Couple Stress Theory

, 2017
Using the modified couple stress theory and the shell model, this paper investigates the torsional instability of carbon nano peapods (CNPs), which are the hybrid structures made by inserting C[Formula: see text] fullerenes into CNT.
Fahimeh Mehralian, Yaghoub Tadi Beni
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Theoretical analysis of effect of MHD, couple stress and slip velocity on squeeze film lubrication of rough Triangular plates

International Journal of Thermofluids
In this study, Christensen's stochastic theory is utilized on rough surfaces' hydrodynamic lubricating effect to examine how surface roughness, couple stress fluid, slip velocity, magnetohydrodynamic (MHD), and the triangular surface interact.
Vinutha R, Hanumagowda B. N, Vasanth K. R, Ganesh Kumar K   +3 more
doaj   +1 more source

Size-dependent buckling instability and recovery of beam-like, architected microstructures

Materials & Design, 2019
Beam-like, architected microstructures (BAMs) can be used in various functional applications, such as micro-electro-mechanical systems (MEMS), energy harvesting, actuation, etc.
Pengcheng Jiao, Amir H. Alavi
doaj   +1 more source