Results 231 to 240 of about 66,987 (302)

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Hemofilters versus hemodialyzers: impacts on cytokine removal during cardiopulmonary bypass in pediatric cardiac surgery: a randomized controlled trial. [PDF]

J Cardiothorac Surg
Abdelazim AM, Alaaeldin B, Amer AM, Rizk A, Mahmoud D, Elsobky Y, Tawfik H, Fadaly AS, Elshazly M.   +8 more
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins. [PDF]

Commun Chem
Humpierre AR, Méndez Y, Kim A, Niemeyer M, Frolov A, Saenz M, Garrido R, Reguera L, Santana-Mederos D, Garcia-Rivera D, Westermann B, Rivera DG.   +11 more
europepmc   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

External Pharmacokinetic Model Evaluation of Caffeine in Critically Ill Neonates With Heart Disease Using Data Collected From a Pragmatic Platform Trial. [PDF]

J Pediatr Pharmacol Ther
Hallock C, Hawk A, Castro C, DiCello J, Storer AL, Sielaty R, Foote HP, Benjamin DK, Helfer VE, Gonzalez D, Zimmerman KO, Hornik CP, Thompson EJ.   +12 more
europepmc   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Protein binding of vancomycin in a large mixed patient population at a university hospital. [PDF]

Antimicrob Agents Chemother
Dejaco A, Lier C, Krautbauer S, Kees F, Dorn C, Kees MG.   +5 more
europepmc   +1 more source

ZnO‐Functionalized Silicon Carbide Ceramic Membranes for Removing Impurities From Biodiesel

International Journal of Ceramic Engineering &Science, Volume 8, Issue 3, May 2026.
Silicon carbide (SiC) ceramic membranes functionalized with zinc oxide (ZnO) were assessed for biodiesel purification through crossflow filtration. The ZnO–SiC membranes effectively retained metallic impurities, especially calcium, sodium, and phosphorus, achieving levels that meet biodiesel quality standards.
Arthur Santos Romero, Nilanjan Santra, Nijhuma Kayal, Nahum Travitzky, J. Vladimir Oliveira, Murilo Daniel de Mello Innocentini, Dachamir Hotza   +6 more
wiley   +1 more source

Biocompatible Gadolinium Oxide Nanoparticles Incorporated Doxorubicin Enables Magnetic Resonance and Photoacoustic Dual Imaging for Cancer Theranostics. [PDF]

Nanomaterials (Basel)
Wang X, Imai Y, Kimura Y, Miura R, Imai H, Kondo T.   +5 more
europepmc   +1 more source