Results 241 to 250 of about 66,269 (304)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Safety evaluation of an extension of use of the food enzyme leucyl aminopeptidase from the non-genetically modified <i>Lichtheimia ramosa</i> strain AE-PER. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Cavanna D, Liu Y.   +14 more
europepmc   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Global profiling of α-glucosidase inhibitors from Citri Reticulatae Pericarpium based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method. [PDF]

PLoS One
Wang H, Yin Q, Lin Z, Ma Q, Zhang Z, Jia J.   +5 more
europepmc   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, Volume 13, Issue 13, 3 March 2026.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

Evaluation of Flat Sheet UF PES Membranes Modified with a Polymerized Coating of Bicontinuous Microemulsion for Wastewater Treatment: Insights from Laboratory MBR Experiments. [PDF]

Membranes (Basel)
De S, Quynh TL, Galiano F, Mancuso R, Gabriele B, Hoinkis J, Figoli A.   +6 more
europepmc   +1 more source

Combining bioaffinity-ultrafiltration with <i>in vivo</i> and <i>in vitro</i> analyses to identify and characterize α-glucosidase inhibitors from <i>Rosa roxburghii</i> Tratt. Fruit. [PDF]

Food Chem X
Zhu M, Peng Z, Wang G.
europepmc   +1 more source

Extraction-driven structural modulation of fucoidans from <i>Sargassum assimile</i> enhances antioxidant and immune-stimulating activities. [PDF]

Food Chem X
Sahragard K, Tabarsa M, Gavlighi HA, Yazdi APG.   +3 more
europepmc   +1 more source

Hypertension in Patients With End-Stage Kidney Disease Requiring Dialysis: Bridging the Divide Between Evidence and Practice. [PDF]

Hypertension
Mayeda L, Bansal N.
europepmc   +1 more source