Results 231 to 240 of about 1,839,177 (303)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Correction: METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation. [PDF]

Cell Death Dis
Lin C, Li T, Wang Y, Lai S, Huang Y, Guo Z, Zhang X, Weng S.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Refining predictors of long-term NEDA-3 status in relapsing-remitting multiple sclerosis: insights from real-world data. [PDF]

Neurol Sci
Guerra T, Bianco A, Esposto C, Intini D, Amati F, Guglielmini G, Caputo F, Paolicelli D, Iaffaldano P.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mode of action-specific and cause-specific retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in anti-SS-A antibody-positive rheumatoid arthritis: The ANSWER cohort study. [PDF]

PLoS One
Nishisaka K, Okano T, Imai T, Tsubosaka M, Kamenaga T, Nakano N, Hayashi S, Yamamoto W, Onishi A, Murakami K, Tsujimoto K, Katsushima M, Yoshikawa A, Kotani T, Amuro H, Son Y, Itami T, Nozaki Y, Nose Y, Yamashita M, Shirasugi I, Yamada H, Nishimura K, Ueda Y, Sendo S, Hashimoto M, Kuroda R, Saegusa J.   +27 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Diagnoses of Multiple Sclerosis and Related Disorders and Disease-Modifying Therapies: A Comparison of the Danish Multiple Sclerosis Registry With Other Danish Health Registries. [PDF]

Brain Behav
Joensen H, Framke E, Pontieri L, Magyari M.   +3 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Clinical and laboratory characteristics of adolescents and young adults with sickle cell disease at steady state in Uganda. [PDF]

PLOS Glob Public Health
Ssekandi AM, Namazzi R, Muwonge H, Kalyesubula R, Munabi IG, Sekaggya-Wiltshere C, Namaganda A, Kimuli I, Akugizibwe R, Kasujja H, Mukunya D, Ndeezi G, Kiguli S.   +12 more
europepmc   +1 more source