Results 61 to 70 of about 95,312 (298)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Upper Sioux Indian Community Trip Report: Assessment of Mold and Moisture Conditions [PDF]
, 2004 Paul Francisco from the Building Research Council (BRC) at the University of Illinois Urbana-Champaign and Robert Nemeth from Magna Systems, Inc. conducted a site visit at the Upper Sioux Indian Community Housing Department (USICHD) on April21-23, 2004 ...
Francisco, Paul, Nemeth, Robert
core
BuildingsInvestigating the mathematical and geometric principles embedded in ancient classic architecture is a significant tradition in the history of architectural development.
Lu Shi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Modular residential buildings as engineering hybrids
Current problems of architecture and urban planning, 2023 The article discusses the varieties of engineering hybrids - modular residential buildings. The genesis and history of modular housing construction are traced. The advantages and problems of modular housing construction are determined. The study identified modern trends in modular construction: 1) the desire for maximum consolidation of construction ...
Halyna Osychenko +2 more
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Coupling problem in thermal systems simulations [PDF]
, 2017 Building energy simulation is playing a key role in building design in order to reduce the energy consumption and, consequently, the CO2 emissions. An object-oriented tool called NEST is used to simulate all the phenomena that appear in a building.
González Esteve, Adrià
core +1 more source
WETWALL - an innovative design concept for the treatment of wastewater at an urban scale [PDF]
, 2018 Rising temperatures, increasing food demand and scarcity of water and land resources highlight the importance of promoting the sustainable expansion of agriculture to our urban environment, while preserving water resources.
Arias, Carlos Alberto +7 more
core +4 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source