Results 81 to 90 of about 2,856,616 (381)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Coupling problem in thermal systems simulations [PDF]

open access: yes, 2017
Building energy simulation is playing a key role in building design in order to reduce the energy consumption and, consequently, the CO2 emissions. An object-oriented tool called NEST is used to simulate all the phenomena that appear in a building.
González Esteve, Adrià
core   +1 more source

Kac-Moody Groups and Cosheaves on Davis Building [PDF]

open access: yes, 2018
We investigate smooth representations of complete Kac-Moody groups. We approach representation theory via geometry, in particular, the group action on the Davis realisation of its Bruhat-Tits building.
Hristova, Katerina, Rumynin, Dmitriy
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

STUDY ON MODULAR HOUSES DESIGN

open access: yesJournal of Industrial Design and Engineering Graphics, 2019
In the field of civil engineering, in the last period emerged and developed the idea of modular constructions, which is in consensus with the alert rhythm of the present times that we are going through, while responding to the requirement of economic ...
Carmen Marza   +2 more
doaj   +4 more sources

Possible defects in wood, wood parameters variability and some of its influence on quality of building structure

open access: yesEngineering Structures and Technologies, 2015
Paper specifies the wood-framed with sheathing construction including phases of realization and exploitation. Methods of investigation based on practice and theory has been employed where practical identification of processes and their phases were ...
Jaroslaw Malesza
doaj   +1 more source

Development of the Performance Prediction Equation for a Modular Ground Heat Exchanger

open access: yesEnergies, 2020
Although ground source heat pump (GSHP) systems are more efficient than conventional air source heat pump (ASHP) systems, their high initial investment cost makes it difficult to introduce them into small buildings. Therefore, the development of a method
Jaemin Kim, Yujin Nam
doaj   +1 more source

Downtown Providence Farmers Market Design [PDF]

open access: yes, 2014
This market essentially combines a marketplace with an existing or new industrial building. The hybrid created results in space that has daily retail sales and hours, as well as other goods available at other times.
Dansereau, Lindsay   +13 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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