Results 41 to 50 of about 69,416 (237)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On the Quantum Invariant for the Spherical Seifert Manifold
, 2005 We study the Witten--Reshetikhin--Turaev SU(2) invariant for the Seifert manifold $S^3/\Gamma$ where $\Gamma$ is a finite subgroup of SU(2). We show that the WRT invariants can be written in terms of the Eichler integral of the modular forms with half ...
A. Cappelli +49 more
core +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On the special values of certain L-series related to half-integral weight modular forms [PDF]
, 2014 Let h be a cuspidal Hecke eigenform of half-integral weight, and En/2+1/2 be Cohen’s Eisenstein series of weight n/2+1/2. For a Dirichlet character χ we define a certain linear combination R(χ)(s, h,En/+1/2) of the Rankin-Selberg convolution products of ...
G. Shimura +7 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Cycle integrals and rational period functions for Γ0+(2) and Γ0+(3)
Open MathematicsFor p∈{2,3}p\in \left\{2,3\right\} and an even integer kk, let Wk−2−(p){W}_{k-2}^{-}\left(p) be the space of period polynomials of weight k−2k-2 on Γ0+(p){\Gamma }_{0}^{+}\left(p) with eigenvalue −1-1 under the Fricke involution.
Choi SoYoung +2 more
doaj +1 more source
On sign changes for almost prime coefficients of half-integral weight modular forms
, 2016 For a half-integral weight modular form $f = \sum_{n=1}^{\infty} a_f(n)n^{\frac{k-1}{2}} q^n$ of weight $k = l +\frac{1}{2}$ on $\Gamma_0(4)$ such that $a_f(n)$ ($n$ $\in$ $\mathbb{N}$) are real, we prove for a fixed suitable natural number $r$ that $a_f(
Krishnamoorthy, Srilakshmi +1 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
, 2013 Let $k$ be an odd integer $\ge 3$ and $N$ a positive integer such that $4 \mid N$. Let $\chi$ be an even Dirichlet character modulo $N$. Shimura decomposes the space of half-integral weight cusp forms $S_{k/2}(N,\chi)$ as a direct sum of $S_0(N,\chi ...
Kohnen W. +3 more
core +1 more source