Results 101 to 110 of about 140,029 (306)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Best approximants in modular function spaces

open access: yes, 1990
In this paper we consider the existence of best approximants in modular function spaces by elements of sublattices. Modular function spaces are the natural generalization of Lp, p > 0, Orlicz, Lorentz, and Köthe spaces.
Kozlowski, Wojciech M   +3 more
core   +1 more source

Modular functions on multilattices [PDF]

open access: yes, 1995
summary:We prove that every modular function on a multilattice $L$ with values in a topological Abelian group generates a uniformity on $L$ which makes the multilattice operations uniformly continuous with respect to the exponential uniformity on the ...
Avallone, Anna
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Fixed point theorem and its application to perturbed integral equations in modular function spaces

open access: yesElectronic Journal of Differential Equations, 2005
In this paper, we present a modular version of Krasnoselskii's fixed point theorem. Then this result is applied to the existence of solutions to perturbed integral equations in modular function spaces.
Ahmed Hajji, Elaidi Hanebaly
doaj  

Modularity in Argyres-Douglas theories with a = c

open access: yesJournal of High Energy Physics
We consider a family of Argyres-Douglas theories, which are 4D N $$ \mathcal{N} $$ = 2 strongly coupled superconformal field theories (SCFTs) but share many features with 4D N $$ \mathcal{N} $$ = 4 super-Yang-Mills theories.
Hongliang Jiang
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Identifying component modules

open access: yes, 2002
A computer-based system for modelling component dependencies and identifying component modules is presented. A variation of the Dependency Structure Matrix (DSM) representation was used to model component dependencies.
Whitfield, R.I.   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

The modular era of functional genomics.

open access: yesGenome biology, 2003
A report on the Keystone Symposium 'Functional Genomics: Global Analysis of Complex Biological Systems', Santa Fe, USA, 20-24 February 2003.
Segal, Eran, Kim, Stuart K
openaire   +2 more sources

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