Results 41 to 50 of about 140,029 (306)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Modular Functional Descriptions
Electronic Notes in Theoretical Computer Science, 2008 AbstractThe construction of reactive systems often requires the combination of different individual functionalities, thus leading to a complex overall behavior. To achieve an efficient construction of reliable systems, a structured approach to the definition of the behavior is needed. Here, functional modularization supports a separation of the overall
openaire +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Weil pairing and the Drinfeld modular curve [PDF]
, 2003 In 1974 verscheen er van de hand van de Oekraïnse wiskundige Vladimir Gershonovich Drinfeld een baanbrekend artikel getiteld 'Elliptic modules'. Met deze elliptische modulen, die tegenwoordig Drinfeld modulen worden genoemd, voegde de toen 19-jarige ...
Heiden, Gerrit Jan van der, +2 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
eLife, 2020 Signaling molecules derived from attachment of diverse metabolic building blocks to ascarosides play a central role in the life history of C. elegans and other nematodes; however, many aspects of their biogenesis remain unclear.
Henry H Le +11 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Modular Quasi-Pseudo Metrics and the Aggregation Problem
MathematicsThe applicability of the distance aggregation problem has attracted the interest of many authors. Motivated by this fact, in this paper, we face the modular quasi-(pseudo-)metric aggregation problem, which consists of analyzing the properties that a ...
Maria del Mar Bibiloni-Femenias +1 more
doaj +1 more source
METHODS OF SOLVING THE PATTERN RECOGNITION PROBLEM USING RESIDUE NUMBER SYSTEM
Наука. Инновации. Технологии, 2022 The paper proposes a possibility of implementing algorithms of solving the pattern recognition problem in the Residue Number System. Considered the most advanced information processing algorithms in the Residue Number System and performed their ...
Nikolay Ivanovich Chervyakov +2 more
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