Results 41 to 50 of about 611,660 (282)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

eLife, 2020
Signaling molecules derived from attachment of diverse metabolic building blocks to ascarosides play a central role in the life history of C. elegans and other nematodes; however, many aspects of their biogenesis remain unclear.
Henry H Le, Chester JJ Wrobel, Sarah M Cohen, Jingfang Yu, Heenam Park, Maximilian J Helf, Brian J Curtis, Joseph C Kruempel, Pedro Reis Rodrigues, Patrick J Hu, Paul W Sternberg, Frank C Schroeder   +11 more
doaj   +1 more source

Two-divisibility of the coefficients of certain weakly holomorphic modular forms

, 2011
We study a canonical basis for spaces of weakly holomorphic modular forms of weights 12, 16, 18, 20, 22, and 26 on the full modular group. We prove a relation between the Fourier coefficients of modular forms in this canonical basis and a generalized ...
A. El-Guindy, A.O.L. Atkin, B.C. Berndt, Darrin Doud, G.H. Hardy, H.-F. Aas, H.-F. Aas, H.P.F. Swinnerton-Dyer, H.P.F. Swinnerton-Dyer, J. Lehner, J. Lehner, John Lopez, K. Ono, M. Griffin, O. Kolberg, Paul Jenkins, T.M. Apostol, W. Duke, W. Stein   +18 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Modular Quasi-Pseudo Metrics and the Aggregation Problem

Mathematics
The applicability of the distance aggregation problem has attracted the interest of many authors. Motivated by this fact, in this paper, we face the modular quasi-(pseudo-)metric aggregation problem, which consists of analyzing the properties that a ...
Maria del Mar Bibiloni-Femenias, Oscar Valero   +1 more
doaj   +1 more source

METHODS OF SOLVING THE PATTERN RECOGNITION PROBLEM USING RESIDUE NUMBER SYSTEM

Наука. Инновации. Технологии, 2022
The paper proposes a possibility of implementing algorithms of solving the pattern recognition problem in the Residue Number System. Considered the most advanced information processing algorithms in the Residue Number System and performed their ...
Nikolay Ivanovich Chervyakov, Pavel Alekseyevich Lyakhov, Kirill Sergeyevich Shulzhenko   +2 more
doaj  

Fake Z

Journal of High Energy Physics, 2023
Recently introduced connections between quantum codes and Narain CFTs provide a simple ansatz to express a modular-invariant function Z τ τ ¯ $$ Z\left(\tau, \overline{\tau}\right) $$ in terms of a multivariate polynomial satisfying certain additional ...
Anatoly Dymarsky, Rohit R. Kalloor
doaj   +1 more source

DynaMod: dynamic functional modularity analysis [PDF]

Nucleic Acids Research, 2010
A comprehensive analysis of enriched functional categories in differentially expressed genes is important to extract the underlying biological processes of genome-wide expression profiles. Moreover, identification of the network of significant functional modules in these dynamic processes is an interesting challenge.
Sun, CH Sun, Choong-Hyun, Hwang, TH Hwang, Tae-Ho, Oh, KM Oh, Ki-Min, Yi, GS Yi, Gwan-Su   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modular equations and distortion functions [PDF]

The Ramanujan Journal, 2007
Modular equations occur in number theory, but it is less known that such equations also occur in the study of deformation properties of quasiconformal mappings. The authors study two important plane quasiconformal distortion functions, obtaining monotonicity and convexity properties, and finding sharp bounds for them.
Anderson, G. D., Qiu, S.-L., Vuorinen, M.   +2 more
openaire   +3 more sources