Results 41 to 50 of about 2,318 (215)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The genus two free boson in Arakelov geometry
Nuclear Physics B, 2020 Using Arakelov geometry, we compute the partition function of the noncompact free boson at genus two. We begin by compiling a list of modular invariants which appear in the Arakelov theory of Riemann surfaces. Using these quantities, we express the genus
Thomas Vandermeulen
doaj +1 more source
Module Design of Self-reconfigurable Modular Robot: A Survey
Journal of Harbin University of Science and Technology, 2021 Self-reconfigurable modular robot is a robot assembled through one or more modules and can be reconstI11cted into another configuration according to the changes of working environment.
DAI Ye +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Modular Quasi-Pseudo Metrics and the Aggregation Problem
MathematicsThe applicability of the distance aggregation problem has attracted the interest of many authors. Motivated by this fact, in this paper, we face the modular quasi-(pseudo-)metric aggregation problem, which consists of analyzing the properties that a ...
Maria del Mar Bibiloni-Femenias +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
METHODS OF SOLVING THE PATTERN RECOGNITION PROBLEM USING RESIDUE NUMBER SYSTEM
Наука. Инновации. Технологии, 2022 The paper proposes a possibility of implementing algorithms of solving the pattern recognition problem in the Residue Number System. Considered the most advanced information processing algorithms in the Residue Number System and performed their ...
Nikolay Ivanovich Chervyakov +2 more
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