Results 71 to 80 of about 140,029 (306)

Controle supervisório modular de sistemas de grande porte [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Proposta de uma abordagem mais eficiente para a síntese de controladores modulares para sistemas a eventos discretos de ...
Queiroz, Max Hering de
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Iterative Approximation of Fixed Point of Multivalued ρ-Quasi-Nonexpansive Mappings in Modular Function Spaces with Applications

Journal of Function Spaces, 2018
Recently, Khan and Abbas initiated the study of approximating fixed points of multivalued nonlinear mappings in modular function spaces. It is our purpose in this study to continue this recent trend in the study of fixed point theory of multivalued ...
Godwin Amechi Okeke, Sheila Amina Bishop, Safeer Hussain Khan   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Preliminary structural design method for modular wing

Hangkong gongcheng jinzhan
Aircraft modular design can increase the types of missions and reduce costs. In the initial stage of wing modular structure design，the unclearness of wingtip deformation limits the ability to assess the contribution differences of structural stiffness ...
FAN Fulei, LI Yi, CHEN Chunying, JIA Zhaohu   +3 more
doaj   +1 more source

Moments of the Dedekind zeta function [PDF]

, 2013
We study analytic aspects of the Dedekind zeta function of a Galois extension. Specifically, we are interested in its mean values. In the first part of this thesis we give a formula for the second moment of the Dedekind zeta function of a quadratic ...
Heap, Winston
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A closure operator respecting the modular $j$-function

, 2021
We prove some unconditional cases of the Existential Closedness problem for the modular $j$-function. For this, we show that for any finitely generated field we can find a "convenient" set of generators. This is done by showing that in any field equipped
Kirby, J, Aslanyan, V, Aslanyan, Vahagn, Kirby, Jonathan, Eterovic, S, Eterović, Sebastian   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Class invariants from a new kind of Weber-like modular equation [PDF]

A technique is described for explicitly evaluating quotients of the Dedekind eta function at quadratic integers. These evaluations do not make use of complex approximations but are found by an entirely `algebraic' method.
Hart, William B.
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